diff --git a/pkgs/development/python-modules/mypy-boto3/default.nix b/pkgs/development/python-modules/mypy-boto3/default.nix
index eda81a2890e3..49b53c16c397 100644
--- a/pkgs/development/python-modules/mypy-boto3/default.nix
+++ b/pkgs/development/python-modules/mypy-boto3/default.nix
@@ -443,8 +443,8 @@ in
       "sha256-dXNkOcMonYrBh4yzeubd+v3mW42s9XpmpfvgbtgoJgY=";
 
   mypy-boto3-ec2 =
-    buildMypyBoto3Package "ec2" "1.43.39"
-      "sha256-iatW0Ijl1hGkkP3tOwC49kvmO3r3BdYfvRclRw+pmbA=";
+    buildMypyBoto3Package "ec2" "1.43.42"
+      "sha256-7Z42WHnCYm5lCBSAUOMjHBtE4n4aQnVXZMPyvhoxS50=";
 
   mypy-boto3-ec2-instance-connect =
     buildMypyBoto3Package "ec2-instance-connect" "1.43.0"