diff --git a/pkgs/development/libraries/gobject-introspection/default.nix b/pkgs/development/libraries/gobject-introspection/default.nix
index 2d8f7104a0a0..925db88c9d01 100644
--- a/pkgs/development/libraries/gobject-introspection/default.nix
+++ b/pkgs/development/libraries/gobject-introspection/default.nix
@@ -1,7 +1,6 @@
 { stdenv
 , lib
 , fetchurl
-, fetchpatch2
 , glib
 , flex
 , bison
@@ -61,11 +60,6 @@ stdenv.mkDerivation (finalAttrs: {
       src = ./absolute_shlib_path.patch;
       inherit nixStoreDir;
     })
-    (fetchpatch2 {
-      name = "setuptools-74.0-compat.patch";
-      url = "https://github.com/GNOME/gobject-introspection/commit/a2139dba59eac283a7f543ed737f038deebddc19.patch";
-      hash = "sha256-n++wpQuJhAEYtcu8LZDC4+Tx1MYuFIMysFgrvz68jWU=";
-    })
   ] ++ lib.optionals x11Support [
     # Hardcode the cairo shared library path in the Cairo gir shipped with this package.
     # https://github.com/NixOS/nixpkgs/issues/34080