diff --git a/pkgs/development/python-modules/starlette-compress/default.nix b/pkgs/development/python-modules/starlette-compress/default.nix
index 35c5b0756b4d..5a2badcf6781 100644
--- a/pkgs/development/python-modules/starlette-compress/default.nix
+++ b/pkgs/development/python-modules/starlette-compress/default.nix
@@ -3,6 +3,7 @@
   buildPythonPackage,
   fetchFromGitHub,
   hatchling,
+  isPyPy,
   brotli,
   brotlicffi,
   starlette,
@@ -27,8 +28,7 @@ buildPythonPackage rec {
   build-system = [ hatchling ];
 
   dependencies = [
-    brotli
-    brotlicffi
+    (if isPyPy then brotlicffi else brotli)
     starlette
     zstandard
   ];