diff --git a/pkgs/development/python-modules/mypy-boto3/default.nix b/pkgs/development/python-modules/mypy-boto3/default.nix
index b98ac0cd1bb1..f855303b80f6 100644
--- a/pkgs/development/python-modules/mypy-boto3/default.nix
+++ b/pkgs/development/python-modules/mypy-boto3/default.nix
@@ -1160,8 +1160,8 @@ in
       "sha256-4/Q39UsUYaluauoaLm6BOej+Krl2VbO1xKKo1orRIkI=";
 
   mypy-boto3-s3 =
-    buildMypyBoto3Package "s3" "1.42.16"
-      "sha256-vaMsTunwjV6D6IqzkGNZJxAhQ4eUZE9qC4qPZ0WUoeQ=";
+    buildMypyBoto3Package "s3" "1.42.21"
+      "sha256-yrcckYqsfZjE10JUTHIuN9jnF4rLi8iKCurXsQNQJtI=";
 
   mypy-boto3-s3control =
     buildMypyBoto3Package "s3control" "1.42.3"