diff --git a/pkgs/top-level/perl-packages.nix b/pkgs/top-level/perl-packages.nix
index 35c9fd88ad80..b0fcca553b30 100644
--- a/pkgs/top-level/perl-packages.nix
+++ b/pkgs/top-level/perl-packages.nix
@@ -7581,6 +7581,9 @@ with self;
     ];
     env.NIX_CFLAGS_COMPILE = "-I${pkgs.openssl.dev}/include";
     env.NIX_CFLAGS_LINK = "-L${lib.getLib pkgs.openssl}/lib -lcrypto";
+    # Needed on Darwin so Crypt::OpenSSL::Guess does not pick /usr/bin/openssl and mix
+    # system libcrypto with the Nix one (perl aborts: "loading libcrypto in an unsafe way").
+    env.OPENSSL_PREFIX = pkgs.openssl;
     meta = {
       description = "Perl wrapper around OpenSSL's AES library";
       license = with lib.licenses; [