diff --git a/pkgs/by-name/mp/mpy-utils/package.nix b/pkgs/by-name/mp/mpy-utils/package.nix
index 4264b0a3a466..73a174e36bf6 100644
--- a/pkgs/by-name/mp/mpy-utils/package.nix
+++ b/pkgs/by-name/mp/mpy-utils/package.nix
@@ -1,30 +1,47 @@
 {
-  stdenv,
   lib,
   python3Packages,
   fetchPypi,
+  fetchpatch2,
 }:
 
 python3Packages.buildPythonApplication (finalAttrs: {
   pname = "mpy-utils";
   version = "0.1.13";
-  format = "setuptools";
+  pyproject = true;
 
   src = fetchPypi {
     inherit (finalAttrs) pname version;
     hash = "sha256-die8hseaidhs9X7mfFvV8C8zn0uyw08gcHNqmjl+2Z4=";
   };
 
-  propagatedBuildInputs = with python3Packages; [
-    fusepy
+  patches = [
+    # https://github.com/nickzoic/mpy-utils/pull/20
+    (fetchpatch2 {
+      name = "use-mfusepy.patch";
+      url = "https://github.com/nickzoic/mpy-utils/commit/1513b4dc1096bd8861792cd13abafd2342fb5510.patch?full_index=1";
+      hash = "sha256-ZgSEP+4yJf/0itApSmVh/hSqW10Ty+/kOjxg+XJsnn4=";
+    })
+  ];
+
+  build-system = with python3Packages; [ setuptools ];
+
+  dependencies = with python3Packages; [
+    mfusepy
     pyserial
   ];
 
+  # Skip mpy_utils.replfuseops: importing it loads libfuse via ctypes, which
+  # requires macFUSE on Darwin and is not available in the build sandbox.
+  pythonImportsCheck = [
+    "mpy_utils"
+    "mpy_utils.replcontrol"
+  ];
+
   meta = {
     description = "MicroPython development utility programs";
     homepage = "https://github.com/nickzoic/mpy-utils";
     license = lib.licenses.mit;
     maintainers = with lib.maintainers; [ aciceri ];
-    broken = stdenv.hostPlatform.isDarwin;
   };
 })