diff --git a/pkgs/by-name/sa/samtools/package.nix b/pkgs/by-name/sa/samtools/package.nix
index 072234599cdc..8de9ffe80a1b 100644
--- a/pkgs/by-name/sa/samtools/package.nix
+++ b/pkgs/by-name/sa/samtools/package.nix
@@ -10,11 +10,11 @@
 
 stdenv.mkDerivation rec {
   pname = "samtools";
-  version = "1.21";
+  version = "1.22.1";
 
   src = fetchurl {
     url = "https://github.com/samtools/samtools/releases/download/${version}/${pname}-${version}.tar.bz2";
-    hash = "sha256-BXJLCDprbwMF/K5SQ6BWzDbPgmMJw8uTR6a4nuP8Wto=";
+    hash = "sha256-Aqpc0LpS4GwggAVOBZ19d6iF3+lxfDHNid/npAR+2g4=";
   };
 
   # tests require `bgzip` from the htslib package