diff --git a/pkgs/development/python-modules/pyfuse3/default.nix b/pkgs/development/python-modules/pyfuse3/default.nix
index 80788cbc2ac5..186b9fc3abb6 100644
--- a/pkgs/development/python-modules/pyfuse3/default.nix
+++ b/pkgs/development/python-modules/pyfuse3/default.nix
@@ -30,6 +30,7 @@ buildPythonPackage rec {
 
   postPatch = ''
     substituteInPlace setup.py \
+      --replace-fail "if DEVELOPER_MODE" "if False" \
       --replace-fail "'pkg-config'" "'$(command -v $PKG_CONFIG)'"
   '';