diff --git a/pkgs/development/python-modules/wxpython/4.2.nix b/pkgs/development/python-modules/wxpython/4.2.nix
index b8c537ce0d71..26c40ea937b3 100644
--- a/pkgs/development/python-modules/wxpython/4.2.nix
+++ b/pkgs/development/python-modules/wxpython/4.2.nix
@@ -29,7 +29,6 @@
   libglvnd,
   libgbm,
   pango,
-  SDL,
   webkitgtk_4_0,
   wxGTK,
   xorgproto,
@@ -71,7 +70,6 @@ buildPythonPackage rec {
     attrdict
     pkg-config
     setuptools
-    SDL
     sip
     which
     wxGTK
@@ -80,7 +78,6 @@ buildPythonPackage rec {
   buildInputs =
     [
       wxGTK
-      SDL
     ]
     ++ lib.optionals stdenv.hostPlatform.isLinux [
       gst_all_1.gst-plugins-base
@@ -108,7 +105,6 @@ buildPythonPackage rec {
 
     export DOXYGEN=${doxygen}/bin/doxygen
     export PATH="${wxGTK}/bin:$PATH"
-    export SDL_CONFIG="${lib.getExe' (lib.getDev SDL) "sdl-config"}"
     export WAF=$PWD/bin/waf
 
     ${python.pythonOnBuildForHost.interpreter} build.py -v --use_syswx dox etg sip --nodoc build_py