diff --git a/pkgs/development/python-modules/rq/default.nix b/pkgs/development/python-modules/rq/default.nix
index 36ddd4d95b34..7eb455a6dc82 100644
--- a/pkgs/development/python-modules/rq/default.nix
+++ b/pkgs/development/python-modules/rq/default.nix
@@ -57,6 +57,11 @@ buildPythonPackage rec {
     kill $REDIS_PID
   '';
 
+  disabledTests = [
+    # https://github.com/rq/rq/commit/fd261d5d8fc0fe604fa396ee6b9c9b7a7bb4142f
+    "test_clean_large_registry"
+  ];
+
   pythonImportsCheck = [
     "rq"
   ];