diff --git a/pkgs/development/libraries/openexr/2.nix b/pkgs/development/libraries/openexr/2.nix
index aca401ee32c9..145cac6d717e 100644
--- a/pkgs/development/libraries/openexr/2.nix
+++ b/pkgs/development/libraries/openexr/2.nix
@@ -6,6 +6,7 @@
   ilmbase,
   fetchpatch,
   cmake,
+  ctestCheckHook,
 }:
 
 stdenv.mkDerivation rec {
@@ -61,6 +62,9 @@ stdenv.mkDerivation rec {
   ++ lib.optional stdenv.hostPlatform.isStatic "-DCMAKE_SKIP_RPATH=ON";
 
   nativeBuildInputs = [ cmake ];
+  nativeCheckInputs = [
+    ctestCheckHook
+  ];
   propagatedBuildInputs = [
     ilmbase
     zlib
@@ -70,6 +74,11 @@ stdenv.mkDerivation rec {
   # https://github.com/AcademySoftwareFoundation/openexr/issues/1281
   doCheck = !stdenv.hostPlatform.isAarch32 && !stdenv.hostPlatform.isi686;
 
+  disabledTests = lib.optionals (stdenv.hostPlatform.isPower64 && stdenv.hostPlatform.isBigEndian) [
+    # https://github.com/AcademySoftwareFoundation/openexr/issues/222
+    "OpenEXR.IlmImf"
+  ];
+
   meta = {
     description = "High dynamic-range (HDR) image file format";
     homepage = "https://www.openexr.com/";