diff --git a/pkgs/development/python-modules/pyqtgraph/default.nix b/pkgs/development/python-modules/pyqtgraph/default.nix
index a66afe76fd4a..854af36e5bcd 100644
--- a/pkgs/development/python-modules/pyqtgraph/default.nix
+++ b/pkgs/development/python-modules/pyqtgraph/default.nix
@@ -1,4 +1,5 @@
 { lib
+, stdenv
 , buildPythonPackage
 , fetchFromGitHub
 , scipy
@@ -52,6 +53,13 @@ buildPythonPackage rec {
     export FONTCONFIG_FILE=${fontsConf}
   '';
 
+  disabledTests = lib.optionals (!(stdenv.isi686 || stdenv.isx86_64)) [
+    # small precision-related differences on other architectures,
+    # upstream doesn't consider it serious.
+    # https://github.com/pyqtgraph/pyqtgraph/issues/2110
+    "test_PolyLineROI"
+  ];
+
   meta = with lib; {
     description = "Scientific Graphics and GUI Library for Python";
     homepage = "https://www.pyqtgraph.org/";