diff --git a/pkgs/development/python-modules/vllm/default.nix b/pkgs/development/python-modules/vllm/default.nix
index 33f3ef4369c7..61e2634cdad7 100644
--- a/pkgs/development/python-modules/vllm/default.nix
+++ b/pkgs/development/python-modules/vllm/default.nix
@@ -283,7 +283,8 @@ buildPythonPackage rec {
   postPatch = ''
     # pythonRelaxDeps does not cover build-system
     substituteInPlace pyproject.toml \
-      --replace-fail "torch ==" "torch >="
+      --replace-fail "torch ==" "torch >=" \
+      --replace-fail "setuptools>=77.0.3,<80.0.0" "setuptools"
 
     # Ignore the python version check because it hard-codes minor versions and
     # lags behind `ray`'s python interpreter support