diff --git a/pkgs/development/python-modules/e2b-code-interpreter/default.nix b/pkgs/development/python-modules/e2b-code-interpreter/default.nix
new file mode 100644
index 000000000000..2e0f21bcf779
--- /dev/null
+++ b/pkgs/development/python-modules/e2b-code-interpreter/default.nix
@@ -0,0 +1,51 @@
+{
+  lib,
+  buildPythonPackage,
+  fetchFromGitHub,
+
+  # build-system
+  poetry-core,
+
+  # dependencies
+  attrs,
+  e2b,
+  httpx,
+}:
+
+buildPythonPackage rec {
+  pname = "e2b-code-interpreter";
+  inherit (e2b) version;
+  pyproject = true;
+
+  src = fetchFromGitHub {
+    owner = "e2b-dev";
+    repo = "code-interpreter";
+    tag = "@e2b/code-interpreter-python@${version}";
+    hash = "sha256-a2rc7BtV+qwtqlB+JtLCs0BKN15yfwmG3XWWO8we2LA=";
+  };
+
+  sourceRoot = "${src.name}/python";
+
+  build-system = [
+    poetry-core
+  ];
+
+  dependencies = [
+    attrs
+    e2b
+    httpx
+  ];
+
+  pythonImportsCheck = [ "e2b_code_interpreter" ];
+
+  # Tests require an API key
+  # e2b.exceptions.AuthenticationException: API key is required, please visit the Team tab at https://e2b.dev/dashboard to get your API key.
+  doCheck = false;
+
+  meta = {
+    description = "E2B Code Interpreter - Stateful code execution";
+    homepage = "https://github.com/e2b-dev/code-interpreter/tree/main/python";
+    license = lib.licenses.asl20;
+    maintainers = with lib.maintainers; [ GaetanLepage ];
+  };
+}
diff --git a/pkgs/development/python-modules/e2b/default.nix b/pkgs/development/python-modules/e2b/default.nix
new file mode 100644
index 000000000000..b69af4f5ca00
--- /dev/null
+++ b/pkgs/development/python-modules/e2b/default.nix
@@ -0,0 +1,63 @@
+{
+  lib,
+  buildPythonPackage,
+  fetchFromGitHub,
+
+  # build-system
+  poetry-core,
+
+  # dependencies
+  attrs,
+  httpcore,
+  httpx,
+  packaging,
+  protobuf,
+  python-dateutil,
+  typing-extensions,
+}:
+
+buildPythonPackage rec {
+  pname = "e2b";
+  version = "1.5.1";
+  pyproject = true;
+
+  src = fetchFromGitHub {
+    owner = "e2b-dev";
+    repo = "E2B";
+    tag = "@e2b/python-sdk@${version}";
+    hash = "sha256-6THRc4rv/mzOWbsN1FpUu56kjvHvVBssK2glNoGdSzI=";
+  };
+
+  sourceRoot = "${src.name}/packages/python-sdk";
+
+  build-system = [
+    poetry-core
+  ];
+
+  pythonRelaxDeps = [
+    "protobuf"
+  ];
+
+  dependencies = [
+    attrs
+    httpcore
+    httpx
+    packaging
+    protobuf
+    python-dateutil
+    typing-extensions
+  ];
+
+  pythonImportsCheck = [ "e2b" ];
+
+  # Tests require an API key
+  # e2b.exceptions.AuthenticationException: API key is required, please visit the Team tab at https://e2b.dev/dashboard to get your API key.
+  doCheck = false;
+
+  meta = {
+    description = "E2B SDK that give agents cloud environments";
+    homepage = "https://github.com/e2b-dev/E2B/blob/main/packages/python-sdk";
+    license = lib.licenses.asl20;
+    maintainers = with lib.maintainers; [ GaetanLepage ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 9989d94c6afa..8dccb4ec940e 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -4379,6 +4379,10 @@ self: super: with self; {
 
   dynd = callPackage ../development/python-modules/dynd { };
 
+  e2b = callPackage ../development/python-modules/e2b { };
+
+  e2b-code-interpreter = callPackage ../development/python-modules/e2b-code-interpreter { };
+
   e3-core = callPackage ../development/python-modules/e3-core { };
 
   e3-testsuite = callPackage ../development/python-modules/e3-testsuite { };