diff --git a/pkgs/by-name/xe/xemu/package.nix b/pkgs/by-name/xe/xemu/package.nix
index 69fd37c9c4f8..1e8deeef7e81 100644
--- a/pkgs/by-name/xe/xemu/package.nix
+++ b/pkgs/by-name/xe/xemu/package.nix
@@ -28,6 +28,9 @@
   which,
   wrapGAppsHook3,
   cacert,
+  darwin,
+  apple-sdk_12,
+  desktopToDarwinBundle,
 }:
 
 stdenv.mkDerivation (finalAttrs: {
@@ -66,6 +69,10 @@ stdenv.mkDerivation (finalAttrs: {
     which
     wrapGAppsHook3
   ]
+  ++ lib.optionals stdenv.hostPlatform.isDarwin [
+    darwin.sigtool
+    desktopToDarwinBundle
+  ]
   ++ (with python3Packages; [
     python
     pyyaml
@@ -79,22 +86,34 @@ stdenv.mkDerivation (finalAttrs: {
     glib
     gtk3
     curl
-    libdrm
     libepoxy
     libpcap
     libsamplerate
     libslirp
-    libgbm
     openssl
-    vte
     vulkan-headers
     vulkan-loader
+  ]
+  ++ lib.optionals stdenv.hostPlatform.isLinux [
+    libdrm
+    libgbm
+    vte
+  ]
+  ++ lib.optionals stdenv.hostPlatform.isDarwin [
+    apple-sdk_12
   ];
 
   configureFlags = [
     "--disable-strip"
     "--target-list=i386-softmmu"
     "--disable-werror"
+  ]
+  ++ lib.optionals stdenv.hostPlatform.isDarwin [
+    # As seen in the official build script ($src/build.sh)
+    "--disable-cocoa"
+  ]
+  ++ lib.optionals (stdenv.hostPlatform.isDarwin && stdenv.hostPlatform.isx86_64) [
+    "--enable-hvf"
   ];
 
   buildFlags = [ "qemu-system-i386" ];
@@ -117,6 +136,11 @@ stdenv.mkDerivation (finalAttrs: {
 
   preConfigure = ''
     configureFlagsArray+=("--extra-cflags=-DXBOX=1 -Wno-error=redundant-decls")
+  ''
+  + lib.optionalString stdenv.hostPlatform.isDarwin ''
+    configureFlagsArray+=("-Wno-implicit-function-declaration")
+  ''
+  + ''
     # When the data below can't be obtained through git, the build process tries
     # to run `XEMU_COMMIT=$(cat XEMU_COMMIT)` (and similar)
     echo '${finalAttrs.version}' > XEMU_VERSION
@@ -127,6 +151,15 @@ stdenv.mkDerivation (finalAttrs: {
     substituteInPlace ./build.ninja --replace /usr/bin/env $(which env)
   '';
 
+  postBuild =
+    lib.optionalString (stdenv.hostPlatform.isDarwin && stdenv.hostPlatform.isx86_64) ''
+      # Needed for HVF acceleration
+      codesign --entitlements $src/accel/hvf/entitlements.plist -f -s - qemu-system-i386-unsigned
+    ''
+    + lib.optionalString stdenv.hostPlatform.isDarwin ''
+      mv qemu-system-i386-unsigned qemu-system-i386
+    '';
+
   installPhase = ''
     runHook preInstall
 
@@ -155,6 +188,6 @@ stdenv.mkDerivation (finalAttrs: {
     license = lib.licenses.gpl2Plus;
     mainProgram = "xemu";
     maintainers = with lib.maintainers; [ marcin-serwin ];
-    platforms = lib.platforms.linux;
+    platforms = lib.platforms.linux ++ lib.platforms.darwin;
   };
 })