diff --git a/maintainers/maintainer-list.nix b/maintainers/maintainer-list.nix
index a836de2aa65b..b5dc620cd74a 100644
--- a/maintainers/maintainer-list.nix
+++ b/maintainers/maintainer-list.nix
@@ -12037,7 +12037,7 @@
     name = "Tiago Castro";
   };
   tilcreator = {
-    name = "Tilman Jackel";
+    name = "TilCreator";
     email = "contact.nixos@tc-j.de";
     matrix = "@tilcreator:matrix.org";
     github = "TilCreator";
diff --git a/pkgs/development/compilers/glslang/default.nix b/pkgs/development/compilers/glslang/default.nix
index 97092950c6a4..7295db0d9d38 100644
--- a/pkgs/development/compilers/glslang/default.nix
+++ b/pkgs/development/compilers/glslang/default.nix
@@ -31,6 +31,11 @@ stdenv.mkDerivation rec {
     ln -s "${spirv-headers.src}" External/spirv-tools/external/spirv-headers
   '';
 
+  # This is a dirty fix for lib/cmake/SPIRVTargets.cmake:51 which includes this directory
+  postInstall = ''
+    mkdir $out/include/External
+  '';
+
   meta = with lib; {
     inherit (src.meta) homepage;
     description = "Khronos reference front-end for GLSL and ESSL";
diff --git a/pkgs/development/libraries/ncnn/cmakelists.patch b/pkgs/development/libraries/ncnn/cmakelists.patch
new file mode 100644
index 000000000000..23499a1b9922
--- /dev/null
+++ b/pkgs/development/libraries/ncnn/cmakelists.patch
@@ -0,0 +1,13 @@
+diff --git a/CMakeLists.txt b/CMakeLists.txt
+index 98611276..989350bb 100644
+--- a/CMakeLists.txt
++++ b/CMakeLists.txt
+@@ -260,6 +260,8 @@ if(NCNN_VULKAN)
+                 include("${GLSLANG_TARGET_DIR}/HLSLTargets.cmake")
+             endif()
+             include("${GLSLANG_TARGET_DIR}/glslangTargets.cmake")
++            include("${GLSLANG_TARGET_DIR}/SPIRV-Tools/SPIRV-ToolsTarget.cmake")
++            include("${GLSLANG_TARGET_DIR}/SPIRV-Tools-opt/SPIRV-Tools-optTargets.cmake")
+             include("${GLSLANG_TARGET_DIR}/SPIRVTargets.cmake")
+ 
+             if (NOT TARGET glslang OR NOT TARGET SPIRV)
diff --git a/pkgs/development/libraries/ncnn/default.nix b/pkgs/development/libraries/ncnn/default.nix
new file mode 100644
index 000000000000..d53e0d9b42ea
--- /dev/null
+++ b/pkgs/development/libraries/ncnn/default.nix
@@ -0,0 +1,50 @@
+{ lib
+, stdenv
+, fetchFromGitHub
+, cmake
+, vulkan-headers
+, vulkan-loader
+, glslang
+, opencv
+, protobuf
+}:
+
+stdenv.mkDerivation rec {
+  pname = "ncnn";
+  version = "20211208";
+
+  src = fetchFromGitHub {
+    owner = "Tencent";
+    repo = pname;
+    rev = version;
+    sha256 = "1c9axrnafksnks7v5fmi6nzs0qim9n6j5kh5d0vfl3b4r22irhqr";
+  };
+
+  patches = [
+    ./cmakelists.patch
+    ./gpu-include.patch
+  ];
+
+  cmakeFlags = [
+    "-DNCNN_CMAKE_VERBOSE=1" # Only for debugging the build
+    "-DNCNN_SHARED_LIB=1"
+    "-DNCNN_ENABLE_LTO=1"
+    "-DNCNN_VULKAN=1"
+    "-DNCNN_BUILD_EXAMPLES=0"
+    "-DNCNN_BUILD_TOOLS=0"
+    "-DNCNN_SYSTEM_GLSLANG=1"
+    "-DNCNN_PYTHON=0" # Should be an attribute
+
+    "-DGLSLANG_TARGET_DIR=${glslang}/lib/cmake"
+  ];
+
+  nativeBuildInputs = [ cmake ];
+  buildInputs = [ vulkan-headers vulkan-loader glslang opencv protobuf ];
+
+  meta = with lib; {
+    description = "ncnn is a high-performance neural network inference framework optimized for the mobile platform";
+    homepage = "https://github.com/Tencent/ncnn";
+    license = licenses.bsd3;
+    maintainers = with maintainers; [ tilcreator ];
+  };
+}
diff --git a/pkgs/development/libraries/ncnn/gpu-include.patch b/pkgs/development/libraries/ncnn/gpu-include.patch
new file mode 100644
index 000000000000..8f751c769947
--- /dev/null
+++ b/pkgs/development/libraries/ncnn/gpu-include.patch
@@ -0,0 +1,13 @@
+diff --git a/src/gpu.cpp b/src/gpu.cpp
+index 51cd7f95..bf7ed828 100644
+--- a/src/gpu.cpp
++++ b/src/gpu.cpp
+@@ -21,7 +21,7 @@
+ #include <vulkan/vulkan.h>
+ 
+ #include "glslang/SPIRV/GlslangToSpv.h"
+-#include "glslang/glslang/Public/ShaderLang.h"
++#include "glslang/Public/ShaderLang.h"
+ 
+ #include "command.h"
+ #include "layer.h"
diff --git a/pkgs/tools/graphics/realesrgan-ncnn-vulkan/cmakelists.patch b/pkgs/tools/graphics/realesrgan-ncnn-vulkan/cmakelists.patch
new file mode 100644
index 000000000000..5ee94a917262
--- /dev/null
+++ b/pkgs/tools/graphics/realesrgan-ncnn-vulkan/cmakelists.patch
@@ -0,0 +1,13 @@
+diff --git a/CMakeLists.txt b/CMakeLists.txt
+index a234caa..cd9d2c5 100644
+--- a/CMakeLists.txt
++++ b/CMakeLists.txt
+@@ -114,6 +114,8 @@ if(USE_SYSTEM_NCNN)
+             include("${GLSLANG_TARGET_DIR}/HLSLTargets.cmake")
+         endif()
+         include("${GLSLANG_TARGET_DIR}/glslangTargets.cmake")
++        include("${GLSLANG_TARGET_DIR}/SPIRV-Tools/SPIRV-ToolsTarget.cmake")
++        include("${GLSLANG_TARGET_DIR}/SPIRV-Tools-opt/SPIRV-Tools-optTargets.cmake")
+         include("${GLSLANG_TARGET_DIR}/SPIRVTargets.cmake")
+ 
+         if (NOT TARGET glslang OR NOT TARGET SPIRV)
diff --git a/pkgs/tools/graphics/realesrgan-ncnn-vulkan/default.nix b/pkgs/tools/graphics/realesrgan-ncnn-vulkan/default.nix
new file mode 100644
index 000000000000..d66a06b7eed2
--- /dev/null
+++ b/pkgs/tools/graphics/realesrgan-ncnn-vulkan/default.nix
@@ -0,0 +1,65 @@
+{ lib
+, stdenv
+, fetchzip
+, fetchFromGitHub
+, cmake
+, spirv-headers
+, vulkan-headers
+, vulkan-loader
+, glslang
+, libgcc
+, libwebp
+, ncnn
+}:
+
+stdenv.mkDerivation rec {
+  pname = "Real-ESRGAN-ncnn-vulkan";
+  version = "0.1.3.2";
+
+  src = fetchFromGitHub {
+    owner = "xinntao";
+    repo = pname;
+    rev = "v${version}";
+    sha256 = "sha256-eLAIlOl1sUxijeVPFG+NscZGxDdtrQqVkMuxhegESHk=";
+  };
+  sourceRoot = "source/src";
+
+  models = fetchzip {
+    # Choose the newst release from https://github.com/xinntao/Real-ESRGAN/releases to update
+    url = "https://github.com/xinntao/Real-ESRGAN/releases/download/v0.2.3.0/realesrgan-ncnn-vulkan-20211212-ubuntu.zip";
+    stripRoot = false;
+    sha256 = "sha256-17k6fewVEXxx7hi+vPXjHAOq4IIUHLh7WC80CwTeFKI=";
+  };
+
+  patches = [
+    ./cmakelists.patch
+    ./models_path.patch
+  ];
+
+  cmakeFlags = [
+    "-DUSE_SYSTEM_NCNN=1"
+    "-DUSE_SYSTEM_WEBP=1"
+
+    "-DGLSLANG_TARGET_DIR=${glslang}/lib/cmake"
+  ];
+
+  nativeBuildInputs = [ cmake ];
+  buildInputs = [ vulkan-headers vulkan-loader glslang libgcc libwebp ncnn ];
+
+  postPatch = ''
+    substituteInPlace main.cpp --replace REPLACE_MODELS $out/share/models
+  '';
+
+  installPhase = ''
+    mkdir -p $out/bin $out/share
+    cp realesrgan-ncnn-vulkan $out/bin/
+    cp -r ${models}/models $out/share
+  '';
+
+  meta = with lib; {
+    description = "NCNN implementation of Real-ESRGAN. Real-ESRGAN aims at developing Practical Algorithms for General Image Restoration.";
+    homepage = "https://github.com/xinntao/Real-ESRGAN-ncnn-vulkan";
+    license = licenses.mit;
+    maintainers = with maintainers; [ tilcreator ];
+  };
+}
diff --git a/pkgs/tools/graphics/realesrgan-ncnn-vulkan/models_path.patch b/pkgs/tools/graphics/realesrgan-ncnn-vulkan/models_path.patch
new file mode 100644
index 000000000000..43b8e4503be2
--- /dev/null
+++ b/pkgs/tools/graphics/realesrgan-ncnn-vulkan/models_path.patch
@@ -0,0 +1,22 @@
+diff --git a/main.cpp b/main.cpp
+index eb6f6c8..b230bed 100644
+--- a/main.cpp
++++ b/main.cpp
+@@ -110,7 +110,7 @@ static void print_usage()
+     fprintf(stderr, "  -o output-path       output image path (jpg/png/webp) or directory\n");
+     fprintf(stderr, "  -s scale             upscale ratio (can be 2, 4. default=4)\n");
+     fprintf(stderr, "  -t tile-size         tile size (>=32/0=auto, default=0) can be 0,0,0 for multi-gpu\n");
+-    fprintf(stderr, "  -m model-path        folder path to pre-trained models(default=models)\n");
++    fprintf(stderr, "  -m model-path        folder path to pre-trained models(default=REPLACE_MODELS)\n");
+     fprintf(stderr, "  -n model-name        model name (default=realesrgan-x4plus, can be realesrgan-x4plus | realesrgan-x4plus-anime | realesrnet-x4plus | RealESRGANv2-animevideo-xsx2 | RealESRGANv2-animevideo-xsx4 | RealESRGANv2-anime-xsx2 | RealESRGANv2-anime-xsx4)\n");
+     fprintf(stderr, "  -g gpu-id            gpu device to use (default=auto) can be 0,1,2 for multi-gpu\n");
+     fprintf(stderr, "  -j load:proc:save    thread count for load/proc/save (default=1:2:2) can be 1:2,2,2:2 for multi-gpu\n");
+@@ -438,7 +438,7 @@ int main(int argc, char** argv)
+     path_t outputpath;
+     int scale = 4;
+     std::vector<int> tilesize;
+-    path_t model = PATHSTR("models");
++    path_t model = PATHSTR("REPLACE_MODELS");
+     path_t modelname = PATHSTR("realesrgan-x4plus");
+     std::vector<int> gpuid;
+     int jobs_load = 1;
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 223f872aaf7a..afba4035aa8f 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -9166,6 +9166,8 @@ with pkgs;
 
   real_time_config_quick_scan = callPackage ../applications/audio/real_time_config_quick_scan { };
 
+  realesrgan-ncnn-vulkan = callPackage ../tools/graphics/realesrgan-ncnn-vulkan { };
+
   react-native-debugger = callPackage ../development/tools/react-native-debugger { };
 
   read-edid = callPackage ../os-specific/linux/read-edid { };
@@ -19015,6 +19017,8 @@ with pkgs;
 
   nanovna-saver = libsForQt5.callPackage ../applications/science/electronics/nanovna-saver { };
 
+  ncnn = callPackage ../development/libraries/ncnn { };
+
   ndpi = callPackage ../development/libraries/ndpi { };
 
   nemo-qml-plugin-dbus = libsForQt5.callPackage ../development/libraries/nemo-qml-plugin-dbus { };