diff --git a/doc/release-notes/rl-2511.section.md b/doc/release-notes/rl-2511.section.md
index 128780d3078d..9eed43b2ac35 100644
--- a/doc/release-notes/rl-2511.section.md
+++ b/doc/release-notes/rl-2511.section.md
@@ -177,6 +177,8 @@
 
 - `python3Packages.heif-image-plugin` has been dropped due to lack of upstream maintenance and breakage. Use `python3Packages.pillow-heif` instead.
 
+- `python3Packages.pyheif` has been dropped due to lack of upstream maintenance and breakage. Use `python3Packages.pillow-heif` instead.
+
 ## Other Notable Changes {#sec-nixpkgs-release-25.11-notable-changes}
 
 <!-- To avoid merge conflicts, consider adding your item at an arbitrary place in the list instead. -->
diff --git a/pkgs/development/python-modules/pyheif/default.nix b/pkgs/development/python-modules/pyheif/default.nix
deleted file mode 100644
index 55e649722d18..000000000000
--- a/pkgs/development/python-modules/pyheif/default.nix
+++ /dev/null
@@ -1,45 +0,0 @@
-{
-  lib,
-  buildPythonPackage,
-  fetchFromGitHub,
-  setuptools,
-  cffi,
-  libheif,
-  piexif,
-  pillow,
-  pytestCheckHook,
-}:
-
-buildPythonPackage rec {
-  pname = "pyheif";
-  version = "0.8.0";
-  pyproject = true;
-
-  src = fetchFromGitHub {
-    owner = "carsales";
-    repo = "pyheif";
-    tag = "release-${version}";
-    hash = "sha256-7De8ekDceSkUcOgK7ppKad5W5qE0yxdS4kbgYVjxTGg=";
-  };
-
-  build-system = [ setuptools ];
-
-  buildInputs = [ libheif ];
-
-  dependencies = [ cffi ];
-
-  pythonImportsCheck = [ "pyheif" ];
-
-  nativeCheckInputs = [
-    piexif
-    pillow
-    pytestCheckHook
-  ];
-
-  meta = with lib; {
-    homepage = "https://github.com/carsales/pyheif";
-    description = "Python interface to libheif library";
-    license = licenses.asl20;
-    maintainers = [ ];
-  };
-}
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index 95e66c0b5fbe..9a4da035be1e 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -577,6 +577,7 @@ mapAliases ({
   pygbm = throw "pygbm has been removed, since it is abandoned and broken"; # added 2023-06-20
   PyGithub = pygithub; # added 2023-02-19
   pyGtkGlade = throw "Glade support for pygtk has been removed"; # added 2022-01-15
+  pyheif = throw "pyheif has been removed due to lack of upstream maintenance and breakage. Use `pillow-heif` instead."; # added 2025-09-17
   pycallgraph = throw "pycallgraph has been removed, it was using setuptools 2to3 translation feature, which has been removed in setuptools 58"; # added 2022-01-18
   pychef = throw "pychef has been removed because it's been archived upstream and abandoned since 2017."; # added 2022-11-14
   PyChromecast = pychromecast; # added 2023-02-19
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 6c38b8ec5bd9..b59cf687af9e 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -13138,8 +13138,6 @@ self: super: with self; {
 
   pyheck = callPackage ../development/python-modules/pyheck { };
 
-  pyheif = callPackage ../development/python-modules/pyheif { };
-
   pyheos = callPackage ../development/python-modules/pyheos { };
 
   pyhepmc = callPackage ../development/python-modules/pyhepmc { };