diff --git a/pkgs/development/python-modules/mypy-boto3/default.nix b/pkgs/development/python-modules/mypy-boto3/default.nix
index ee36d60468d3..6570a45fde0f 100644
--- a/pkgs/development/python-modules/mypy-boto3/default.nix
+++ b/pkgs/development/python-modules/mypy-boto3/default.nix
@@ -443,8 +443,8 @@ in
       "sha256-dXNkOcMonYrBh4yzeubd+v3mW42s9XpmpfvgbtgoJgY=";
 
   mypy-boto3-ec2 =
-    buildMypyBoto3Package "ec2" "1.43.43"
-      "sha256-S3gWPq+pTKmx5td0D/c78hRjAzhQ+U+vpb6wKWG0cF0=";
+    buildMypyBoto3Package "ec2" "1.43.45"
+      "sha256-xT9yYnd7XfKbajmSfMOjaqYF7YnzwXOe1wtb5vy/wSI=";
 
   mypy-boto3-ec2-instance-connect =
     buildMypyBoto3Package "ec2-instance-connect" "1.43.0"