diff --git a/pkgs/development/python-modules/grpcio-status/default.nix b/pkgs/development/python-modules/grpcio-status/default.nix
index 77ac855e1f6f..db2ece3e21c3 100644
--- a/pkgs/development/python-modules/grpcio-status/default.nix
+++ b/pkgs/development/python-modules/grpcio-status/default.nix
@@ -9,16 +9,21 @@
 
 buildPythonPackage rec {
   pname = "grpcio-status";
-  version = "1.48.1";
+  version = "1.49.1";
   format = "setuptools";
 
   disabled = pythonOlder "3.6";
 
   src = fetchPypi {
     inherit pname version;
-    sha256 = "655af4d0d6e67586cb2ca24c3db5fe08e4e2972d17f295f6b546fa7bd7eef1f6";
+    sha256 = "sha256-ZY9I3BRu4Me27r0wLXTg1FwAcnwgA1/1HWh1DbrM9dk=";
   };
 
+  postPatch = ''
+    substituteInPlace setup.py \
+    --replace 'protobuf>=4.21.3' 'protobuf'
+  '';
+
   propagatedBuildInputs = [
     googleapis-common-protos
     grpcio