diff --git a/pkgs/development/libraries/glib/default.nix b/pkgs/development/libraries/glib/default.nix
index 7fffaa236e55..22e14f308887 100644
--- a/pkgs/development/libraries/glib/default.nix
+++ b/pkgs/development/libraries/glib/default.nix
@@ -130,6 +130,9 @@ stdenv.mkDerivation (finalAttrs: {
     # and by default meson installs in to $out/share/gdb/auto-load
     # which does not help
     ./gdb_script.patch
+
+    # glib assumes that `RTLD_LOCAL` is defined to `0`, which is true on Linux and FreeBSD but not on Darwin.
+    ./gmodule-rtld_local.patch
   ];
 
   outputs = [ "bin" "out" "dev" "devdoc" ];
diff --git a/pkgs/development/libraries/glib/gmodule-rtld_local.patch b/pkgs/development/libraries/glib/gmodule-rtld_local.patch
new file mode 100644
index 000000000000..abbf19d70b20
--- /dev/null
+++ b/pkgs/development/libraries/glib/gmodule-rtld_local.patch
@@ -0,0 +1,13 @@
+diff --git a/gmodule/gmodule-dl.c b/gmodule/gmodule-dl.c
+index 6d1c5fab7..b21773bca 100644
+--- a/gmodule/gmodule-dl.c
++++ b/gmodule/gmodule-dl.c
+@@ -136,7 +136,7 @@ _g_module_open (const gchar *file_name,
+   
+   lock_dlerror ();
+   handle = dlopen (file_name,
+-		   (bind_local ? 0 : RTLD_GLOBAL) | (bind_lazy ? RTLD_LAZY : RTLD_NOW));
++		   (bind_local ? RTLD_LOCAL : RTLD_GLOBAL) | (bind_lazy ? RTLD_LAZY : RTLD_NOW));
+   if (!handle)
+     {
+       const gchar *message = fetch_dlerror (TRUE);