diff --git a/pkgs/development/python-modules/pywfa/default.nix b/pkgs/development/python-modules/pywfa/default.nix
new file mode 100644
index 000000000000..529417db9896
--- /dev/null
+++ b/pkgs/development/python-modules/pywfa/default.nix
@@ -0,0 +1,53 @@
+{ lib
+, buildPythonPackage
+, fetchFromGitHub
+, pythonOlder
+, cython
+, setuptools
+, wheel
+, pysam
+, unittestCheckHook
+}:
+
+buildPythonPackage rec {
+  pname = "pywfa";
+  version = "0.5.1";
+  pyproject = true;
+
+  disabled = pythonOlder "3.7";
+
+  src = fetchFromGitHub {
+    owner = "kcleal";
+    repo = "pywfa";
+    rev = "refs/tags/v${version}";
+    hash = "sha256-oeVXK9uyH4E98tApKrA7dXifQYb41KuDTAZ40XgAaF8=";
+  };
+
+  nativeBuildInputs = [
+    cython
+    setuptools
+    wheel
+  ];
+
+  nativeCheckInputs = [
+    pysam
+    unittestCheckHook
+  ];
+
+  preCheck = ''
+    cd pywfa/tests
+  '';
+
+  pythonImportsCheck = [
+    "pywfa"
+    "pywfa.align"
+  ];
+
+  meta = with lib; {
+    description = "Python wrapper for wavefront alignment using WFA2-lib";
+    homepage = "https://github.com/kcleal/pywfa";
+    changelog = "https://github.com/kcleal/pywfa/releases/tag/${src.rev}";
+    license = licenses.mit;
+    maintainers = with maintainers; [ natsukium ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 84c900aa0ef9..b9d8033ddffe 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -11705,6 +11705,8 @@ self: super: with self; {
 
   pywerview = callPackage ../development/python-modules/pywerview { };
 
+  pywfa = callPackage ../development/python-modules/pywfa { };
+
   pywilight = callPackage ../development/python-modules/pywilight { };
 
   pywinrm = callPackage ../development/python-modules/pywinrm { };