diff --git a/pkgs/development/python-modules/asdf-astropy/default.nix b/pkgs/development/python-modules/asdf-astropy/default.nix
new file mode 100644
index 000000000000..1ee09ad98332
--- /dev/null
+++ b/pkgs/development/python-modules/asdf-astropy/default.nix
@@ -0,0 +1,70 @@
+{
+  lib,
+  asdf-coordinates-schemas,
+  asdf-standard,
+  asdf-transform-schemas,
+  asdf,
+  astropy,
+  buildPythonPackage,
+  fetchFromGitHub,
+  numpy,
+  packaging,
+  pytest-astropy,
+  pytestCheckHook,
+  pythonOlder,
+  scipy,
+  setuptools-scm,
+  setuptools,
+  tomli,
+  wheel,
+}:
+
+buildPythonPackage rec {
+  pname = "asdf-astropy";
+  version = "0.6.1";
+  pyproject = true;
+
+  disabled = pythonOlder "3.10";
+
+  src = fetchFromGitHub {
+    owner = "astropy";
+    repo = "asdf-astropy";
+    rev = "refs/tags/${version}";
+    hash = "sha256-dOd9QdBOu7QotRiHkXJoIqaHG6U9odTlRmy22/nvvuw=";
+  };
+
+  nativeBuildInputs = [
+    setuptools
+    setuptools-scm
+  ];
+
+  propagatedBuildInputs = [
+    asdf
+    asdf-coordinates-schemas
+    asdf-standard
+    asdf-transform-schemas
+    astropy
+    numpy
+    packaging
+  ];
+
+  nativeCheckInputs = [
+    pytest-astropy
+    pytestCheckHook
+    scipy
+  ];
+
+  pythonImportsCheck = [ "asdf_astropy" ];
+
+  preCheck = ''
+    export HOME=$(mktemp -d)
+  '';
+
+  meta = with lib; {
+    description = "Extension library for ASDF to provide support for Astropy";
+    homepage = "https://github.com/astropy/asdf-astropy";
+    changelog = "https://github.com/astropy/asdf-astropy/blob/${version}/CHANGES.rst";
+    license = licenses.bsd3;
+    maintainers = with maintainers; [ fab ];
+  };
+}
diff --git a/pkgs/development/python-modules/asdf-coordinates-schemas/default.nix b/pkgs/development/python-modules/asdf-coordinates-schemas/default.nix
new file mode 100644
index 000000000000..9b2c103ac13f
--- /dev/null
+++ b/pkgs/development/python-modules/asdf-coordinates-schemas/default.nix
@@ -0,0 +1,48 @@
+{
+  lib,
+  asdf-standard,
+  asdf,
+  buildPythonPackage,
+  fetchFromGitHub,
+  pythonOlder,
+  setuptools-scm,
+  setuptools,
+}:
+
+buildPythonPackage rec {
+  pname = "asdf-coordinates-schemas";
+  version = "0.3.0";
+  pyproject = true;
+
+  disabled = pythonOlder "3.10";
+
+  src = fetchFromGitHub {
+    owner = "asdf-format";
+    repo = "asdf-coordinates-schemas";
+    rev = "refs/tags/${version}";
+    hash = "sha256-LuC0m25OqQwivK/Z3OfoCtdhBV87rk16XrkJxUxG07o=";
+  };
+
+  build-system = [
+    setuptools
+    setuptools-scm
+  ];
+
+  dependencies = [
+    asdf
+    asdf-standard
+  ];
+
+  # Circular dependency with asdf-astropy
+  doCheck = false;
+
+  pythonImportsCheck = [ "asdf_coordinates_schemas" ];
+
+  meta = with lib; {
+    description = "ASDF schemas for coordinates";
+    homepage = "https://github.com/asdf-format/asdf-coordinates-schemas";
+    changelog = "https://github.com/asdf-format/asdf-coordinates-schemas/blob/${version}/CHANGES.rst";
+    license = licenses.bsd3;
+    maintainers = with maintainers; [ fab ];
+  };
+}
diff --git a/pkgs/development/python-modules/asdf-wcs-schemas/default.nix b/pkgs/development/python-modules/asdf-wcs-schemas/default.nix
new file mode 100644
index 000000000000..f59b2cb98803
--- /dev/null
+++ b/pkgs/development/python-modules/asdf-wcs-schemas/default.nix
@@ -0,0 +1,56 @@
+{
+  lib,
+  asdf-astropy,
+  asdf-coordinates-schemas,
+  asdf-standard,
+  asdf-transform-schemas,
+  asdf,
+  buildPythonPackage,
+  fetchFromGitHub,
+  pytestCheckHook,
+  pythonOlder,
+  setuptools-scm,
+  setuptools,
+}:
+
+buildPythonPackage rec {
+  pname = "asdf-wcs-schemas";
+  version = "0.4.0";
+  pyproject = true;
+
+  disabled = pythonOlder "3.10";
+
+  src = fetchFromGitHub {
+    owner = "asdf-format";
+    repo = "asdf-wcs-schemas";
+    rev = "refs/tags/${version}";
+    hash = "sha256-4CxKLMYXdNkNwkfFRX3YKkS4e+Z3wQgmz8ogbC4Z1vI=";
+  };
+
+  build-system = [
+    setuptools
+    setuptools-scm
+  ];
+
+  dependencies = [
+    asdf-coordinates-schemas
+    asdf-standard
+    asdf-transform-schemas
+  ];
+
+  nativeCheckInputs = [
+    asdf
+    asdf-astropy
+    pytestCheckHook
+  ];
+
+  pythonImportsCheck = [ "asdf_wcs_schemas" ];
+
+  meta = with lib; {
+    description = "World Coordinate System (WCS) ASDF schemas";
+    homepage = "https://github.com/asdf-format/asdf-wcs-schemas";
+    changelog = "https://github.com/asdf-format/asdf-wcs-schemas/blob/${version}/CHANGES.rst";
+    license = licenses.bsd3;
+    maintainers = with maintainers; [ fab ];
+  };
+}
diff --git a/pkgs/development/python-modules/extension-helpers/default.nix b/pkgs/development/python-modules/extension-helpers/default.nix
new file mode 100644
index 000000000000..56f6a8f4d0a8
--- /dev/null
+++ b/pkgs/development/python-modules/extension-helpers/default.nix
@@ -0,0 +1,57 @@
+{
+  lib,
+  buildPythonPackage,
+  cython,
+  fetchFromGitHub,
+  pip,
+  pytestCheckHook,
+  pythonOlder,
+  setuptools-scm,
+  setuptools,
+  tomli,
+  wheel,
+}:
+
+buildPythonPackage rec {
+  pname = "extension-helpers";
+  version = "1.1.1";
+  pyproject = true;
+
+  disabled = pythonOlder "3.8";
+
+  src = fetchFromGitHub {
+    owner = "astropy";
+    repo = "extension-helpers";
+    rev = "refs/tags/v${version}";
+    hash = "sha256-pYCSLb6uuQ9ZtMZOQH0DxLlfgFv3tgH+AL35IN71cNI=";
+  };
+
+  build-system = [
+    setuptools
+    setuptools-scm
+  ];
+
+  dependencies = [ setuptools ] ++ lib.optionals (pythonOlder "3.11") [ tomli ];
+
+  nativeCheckInputs = [
+    pytestCheckHook
+    pip
+  ];
+
+  pythonImportsCheck = [ "extension_helpers" ];
+
+  pytestFlagsArray = [ "extension_helpers/tests" ];
+
+  disabledTests = [
+    # Test require network access
+    "test_only_pyproject"
+  ];
+
+  meta = with lib; {
+    description = "Helpers to assist with building Python packages with compiled C/Cython extensions";
+    homepage = "https://github.com/astropy/extension-helpers";
+    changelog = "https://github.com/astropy/extension-helpers/blob/${version}/CHANGES.md";
+    license = licenses.bsd3;
+    maintainers = with maintainers; [ fab ];
+  };
+}
diff --git a/pkgs/development/python-modules/gwcs/default.nix b/pkgs/development/python-modules/gwcs/default.nix
new file mode 100644
index 000000000000..a6dd4fcae507
--- /dev/null
+++ b/pkgs/development/python-modules/gwcs/default.nix
@@ -0,0 +1,61 @@
+{
+  lib,
+  asdf-astropy,
+  asdf-wcs-schemas,
+  asdf,
+  astropy,
+  buildPythonPackage,
+  fetchFromGitHub,
+  numpy,
+  pytest-astropy,
+  pytestCheckHook,
+  pythonOlder,
+  scipy,
+  setuptools-scm,
+  setuptools,
+  tomli,
+}:
+
+buildPythonPackage rec {
+  pname = "gwcs";
+  version = "0.21.0";
+  pyproject = true;
+
+  disabled = pythonOlder "3.10";
+
+  src = fetchFromGitHub {
+    owner = "spacetelescope";
+    repo = "gwcs";
+    rev = "refs/tags/${version}";
+    hash = "sha256-76h2lDIaPHj7HarVcE0t5k6CA/hLCwquaz+2wMsKj+Y=";
+  };
+
+  build-system = [
+    setuptools
+    setuptools-scm
+  ];
+
+  dependencies = [
+    asdf
+    asdf-astropy
+    asdf-wcs-schemas
+    astropy
+    numpy
+    scipy
+  ];
+
+  nativeCheckInputs = [
+    pytest-astropy
+    pytestCheckHook
+  ];
+
+  pythonImportsCheck = [ "gwcs" ];
+
+  meta = with lib; {
+    description = "Module to manage the Generalized World Coordinate System";
+    homepage = "https://github.com/spacetelescope/gwcs";
+    changelog = "https://github.com/spacetelescope/gwcs/blob/${version}/CHANGES.rst";
+    license = licenses.bsd3;
+    maintainers = with maintainers; [ fab ];
+  };
+}
diff --git a/pkgs/development/python-modules/photutils/default.nix b/pkgs/development/python-modules/photutils/default.nix
new file mode 100644
index 000000000000..091e9cfd9741
--- /dev/null
+++ b/pkgs/development/python-modules/photutils/default.nix
@@ -0,0 +1,89 @@
+{
+  lib,
+  astropy,
+  bottleneck,
+  buildPythonPackage,
+  cython,
+  extension-helpers,
+  fetchFromGitHub,
+  gwcs,
+  matplotlib,
+  numpy,
+  photutils,
+  pythonOlder,
+  rasterio,
+  scikit-image,
+  scikit-learn,
+  scipy,
+  setuptools-scm,
+  setuptools,
+  shapely,
+  tomli,
+  tqdm,
+  python,
+  wheel,
+}:
+
+buildPythonPackage rec {
+  pname = "photutils";
+  version = "1.12.0";
+  pyproject = true;
+
+  disabled = pythonOlder "3.10";
+
+  src = fetchFromGitHub {
+    owner = "astropy";
+    repo = "photutils";
+    rev = "refs/tags/${version}";
+    hash = "sha256-k5MxpkCAvefSRoNPMAVIvNcCTU5HPicU4XSFXk13O9Q=";
+  };
+
+  postPatch = ''
+    substituteInPlace pyproject.toml \
+      --replace-fail "'numpy>=2.0.0rc1'," ""
+  '';
+
+  build-system = [
+    setuptools
+    setuptools-scm
+    wheel
+  ];
+
+  nativeBuildInputs = [
+    cython
+    extension-helpers
+    numpy
+  ];
+
+  dependencies = [
+    astropy
+    numpy
+  ];
+
+  passthru.optional-dependencies = {
+    all = [
+      bottleneck
+      gwcs
+      matplotlib
+      rasterio
+      scikit-image
+      scikit-learn
+      scipy
+      shapely
+      tqdm
+    ];
+  };
+
+  # With 1.12.0 tests have issues importing modules
+  doCheck = false;
+
+  pythonImportsCheck = [ "photutils" ];
+
+  meta = with lib; {
+    description = "Astropy package for source detection and photometry";
+    homepage = "https://github.com/astropy/photutils";
+    changelog = "https://github.com/astropy/photutils/blob/${version}/CHANGES.rst";
+    license = licenses.bsd3;
+    maintainers = with maintainers; [ fab ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 0d1d64ac58b6..076e5131f1b8 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -787,10 +787,16 @@ self: super: with self; {
 
   asdf = callPackage ../development/python-modules/asdf { };
 
+  asdf-astropy = callPackage ../development/python-modules/asdf-astropy { };
+
+  asdf-coordinates-schemas = callPackage ../development/python-modules/asdf-coordinates-schemas { };
+
   asdf-standard = callPackage ../development/python-modules/asdf-standard { };
 
   asdf-transform-schemas = callPackage ../development/python-modules/asdf-transform-schemas { };
 
+  asdf-wcs-schemas = callPackage ../development/python-modules/asdf-wcs-schemas { };
+
   ase = callPackage ../development/python-modules/ase { };
 
   asf-search = callPackage ../development/python-modules/asf-search { };
@@ -4043,6 +4049,8 @@ self: super: with self; {
 
   exitcode = callPackage ../development/python-modules/exitcode { };
 
+  extension-helpers = callPackage ../development/python-modules/extension-helpers { };
+
   extract-msg = callPackage ../development/python-modules/extract-msg { };
 
   extractcode = callPackage ../development/python-modules/extractcode { };
@@ -5279,6 +5287,8 @@ self: super: with self; {
 
   gviz-api = callPackage ../development/python-modules/gviz-api { };
 
+  gwcs = callPackage ../development/python-modules/gwcs { };
+
   gym = callPackage ../development/python-modules/gym { };
 
   gym-notices = callPackage ../development/python-modules/gym-notices { };
@@ -9784,6 +9794,8 @@ self: super: with self; {
 
   phonenumbers = callPackage ../development/python-modules/phonenumbers { };
 
+  photutils = callPackage ../development/python-modules/photutils { };
+
   pkgutil-resolve-name = callPackage ../development/python-modules/pkgutil-resolve-name { };
 
   pkg-about = callPackage ../development/python-modules/pkg-about { };