diff --git a/pkgs/development/python-modules/python-u2flib-server/default.nix b/pkgs/development/python-modules/python-u2flib-server/default.nix
deleted file mode 100644
index fa93cb83fce8..000000000000
--- a/pkgs/development/python-modules/python-u2flib-server/default.nix
+++ /dev/null
@@ -1,54 +0,0 @@
-{
-  lib,
-  buildPythonPackage,
-  fetchFromGitHub,
-
-  # propagates
-  cryptography,
-  six,
-
-  # optional
-  webob,
-
-  # tests
-  pytestCheckHook,
-}:
-
-buildPythonPackage rec {
-  pname = "python-u2flib-server";
-  version = "5.0.1";
-  format = "setuptools";
-
-  src = fetchFromGitHub {
-    owner = "Yubico";
-    repo = "python-u2flib-server";
-    rev = version;
-    hash = "sha256-ginP9u+aHcdaWpwcFYJWu0Ghf7+nDZq9i3TVAacIPhg=";
-  };
-
-  patches = [ ./cryptography-37-compat.patch ];
-
-  propagatedBuildInputs = [
-    cryptography
-    six
-  ];
-
-  optional-dependencies = {
-    u2f_server = [ webob ];
-  };
-
-  pythonImportsCheck = [
-    "u2flib_server"
-    "u2flib_server.u2f"
-  ];
-
-  nativeCheckInputs = [ pytestCheckHook ] ++ optional-dependencies.u2f_server;
-
-  meta = with lib; {
-    description = "Python based U2F server library";
-    homepage = "https://github.com/Yubico/python-u2flib-server";
-    changelog = "https://github.com/Yubico/python-u2flib-server/blob/${src.rev}/NEWS";
-    license = licenses.bsd2;
-    maintainers = with maintainers; [ hexa ];
-  };
-}
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index bd55bef928de..3e414d290a60 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -364,6 +364,7 @@ mapAliases {
   python-lz4 = throw "'python-lz4' has been renamed to/replaced by 'lz4'"; # Converted to throw 2025-10-29
   python-simple-hipchat = throw "'python-simple-hipchat' has been removed because it was broken and unmaintained"; # added 2025-08-26
   python-subunit = throw "'python-subunit' has been renamed to/replaced by 'subunit'"; # Converted to throw 2025-10-29
+  python-u2flib-server = throw "'python-u2flib-server' has been removed, since it was broken and archived upstream"; # added 2025-11-08
   python-unshare = throw "python-unshare was removed as unmaintained since 2016"; # added 2025-05-25
   python_docs_theme = throw "'python_docs_theme' has been renamed to/replaced by 'python-docs-theme'"; # Converted to throw 2025-10-29
   python_fedora = throw "'python_fedora' has been renamed to/replaced by 'python-fedora'"; # Converted to throw 2025-10-29
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index ecc31ff35bc8..8a1afebd819d 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -15312,8 +15312,6 @@ self: super: with self; {
 
   python-u2flib-host = callPackage ../development/python-modules/python-u2flib-host { };
 
-  python-u2flib-server = callPackage ../development/python-modules/python-u2flib-server { };
-
   python-uinput = callPackage ../development/python-modules/python-uinput { };
 
   python-ulid = callPackage ../development/python-modules/python-ulid { };