diff --git a/pkgs/development/python-modules/pyqldb/default.nix b/pkgs/development/python-modules/pyqldb/default.nix
deleted file mode 100644
index 3a6689228c4c..000000000000
--- a/pkgs/development/python-modules/pyqldb/default.nix
+++ /dev/null
@@ -1,45 +0,0 @@
-{
-  lib,
-  buildPythonPackage,
-  fetchFromGitHub,
-  boto3,
-  amazon-ion,
-  ionhash,
-  pytestCheckHook,
-}:
-
-buildPythonPackage rec {
-  pname = "pyqldb";
-  version = "3.2.4";
-  format = "setuptools";
-
-  src = fetchFromGitHub {
-    owner = "awslabs";
-    repo = "amazon-qldb-driver-python";
-    tag = "v${version}";
-    hash = "sha256-u8wI8ThD/BA+WI62OvNFmYvcqr018wgrh+5J+p2A6hM=";
-  };
-
-  propagatedBuildInputs = [
-    boto3
-    amazon-ion
-    ionhash
-  ];
-
-  nativeCheckInputs = [ pytestCheckHook ];
-
-  preCheck = ''
-    export AWS_DEFAULT_REGION=us-east-1
-  '';
-
-  enabledTestPaths = [ "tests/unit" ];
-
-  pythonImportsCheck = [ "pyqldb" ];
-
-  meta = with lib; {
-    description = "Python driver for Amazon QLDB";
-    homepage = "https://github.com/awslabs/amazon-qldb-driver-python";
-    license = licenses.asl20;
-    maintainers = [ maintainers.terlar ];
-  };
-}
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index fc86c50cf5a4..a4804ad94421 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -583,6 +583,7 @@ mapAliases ({
   python-picnic-api = throw "python-picnic-api was removed because Home Assistant switched to python-picnic-api2"; # added 2025-03-05
   python-unshare = throw "python-unshare was removed as unmaintained since 2016"; # added 2025-05-25
   pytrends = throw "pytrends has been removed, as it no longer works and is abandoned upstream"; # added 2025-02-02
+  pyqldb = throw "pyqldb has been removed, because the underlying service is reaching end of support"; # added 2025-07-30
   pyqt4 = throw "pyqt4 has been removed, because it depended on the long EOL qt4"; # added 2022-06-09
   pyqt5_sip = pyqt5-sip; # added 2024-01-07
   pyqt5_with_qtmultimedia = pyqt5-multimedia; # added 2024-01-07
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 38a9d405f8cc..7eb858500071 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -13579,8 +13579,6 @@ self: super: with self; {
 
   pypytools = callPackage ../development/python-modules/pypytools { };
 
-  pyqldb = callPackage ../development/python-modules/pyqldb { };
-
   pyqrcode = callPackage ../development/python-modules/pyqrcode { };
 
   pyqt-builder = callPackage ../development/python-modules/pyqt-builder { };