diff --git a/pkgs/development/interpreters/python/cpython/default.nix b/pkgs/development/interpreters/python/cpython/default.nix
index 083c33cee838..9feaf2a57f06 100644
--- a/pkgs/development/interpreters/python/cpython/default.nix
+++ b/pkgs/development/interpreters/python/cpython/default.nix
@@ -47,12 +47,6 @@
   gdbm,
   withReadline ? !withMinimalDeps && !stdenv.hostPlatform.isWindows,
   readline,
-  x11Support ? false,
-  tcl,
-  tk,
-  tclPackages,
-  libX11,
-  xorgproto,
 
   # splicing/cross
   pythonAttr ? "python${sourceVersion.major}${sourceVersion.minor}",
@@ -114,8 +108,6 @@
 # cgit) that are needed here should be included directly in Nixpkgs as
 # files.
 
-assert x11Support -> tcl != null && tk != null && xorgproto != null && libX11 != null;
-
 assert bluezSupport -> bluez != null;
 
 assert lib.assertMsg (
@@ -280,12 +272,6 @@ let
     ++ optionals withReadline [
       readline
     ]
-    ++ optionals x11Support [
-      libX11
-      tcl
-      tk
-      xorgproto
-    ]
   );
 
   hasDistutilsCxxPatch = !(stdenv.cc.isGNU or false);
@@ -446,11 +432,6 @@ stdenv.mkDerivation (finalAttrs: {
     + optionalString mimetypesSupport ''
       substituteInPlace Lib/mimetypes.py \
         --replace-fail "@mime-types@" "${mailcap}"
-    ''
-    + optionalString (pythonOlder "3.13" && x11Support && ((tclPackages.tix or null) != null)) ''
-      substituteInPlace "Lib/tkinter/tix.py" --replace-fail \
-        "os.environ.get('TIX_LIBRARY')" \
-        "os.environ.get('TIX_LIBRARY') or '${tclPackages.tix}/lib'"
     '';
 
   env = {
@@ -581,10 +562,6 @@ stdenv.mkDerivation (finalAttrs: {
         if stdenv.hostPlatform.isAarch64 then "uint128" else "x64"
       }'
   ''
-  + optionalString (stdenv.hostPlatform.isDarwin && x11Support && pythonAtLeast "3.11") ''
-    export TCLTK_LIBS="-L${tcl}/lib -L${tk}/lib -l${tcl.libPrefix} -l${tk.libPrefix}"
-    export TCLTK_CFLAGS="-I${tcl}/include -I${tk}/include"
-  ''
   + optionalString stdenv.hostPlatform.isWindows ''
     export NIX_CFLAGS_COMPILE+=" -Wno-error=incompatible-pointer-types"
   ''
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 6b877a611f96..54dd9f502ab9 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -6206,37 +6206,31 @@ with pkgs;
     self = python3Full;
     pythonAttr = "python3Full";
     bluezSupport = lib.meta.availableOn stdenv.hostPlatform bluez;
-    x11Support = true;
   };
   python310Full = python310.override {
     self = python310Full;
     pythonAttr = "python310Full";
     bluezSupport = lib.meta.availableOn stdenv.hostPlatform bluez;
-    x11Support = true;
   };
   python311Full = python311.override {
     self = python311Full;
     pythonAttr = "python311Full";
     bluezSupport = lib.meta.availableOn stdenv.hostPlatform bluez;
-    x11Support = true;
   };
   python312Full = python312.override {
     self = python312Full;
     pythonAttr = "python312Full";
     bluezSupport = lib.meta.availableOn stdenv.hostPlatform bluez;
-    x11Support = true;
   };
   python313Full = python313.override {
     self = python313Full;
     pythonAttr = "python313Full";
     bluezSupport = lib.meta.availableOn stdenv.hostPlatform bluez;
-    x11Support = true;
   };
   python314Full = python314.override {
     self = python314Full;
     pythonAttr = "python314Full";
     bluezSupport = lib.meta.availableOn stdenv.hostPlatform bluez;
-    x11Support = true;
   };
 
   # https://py-free-threading.github.io