diff --git a/pkgs/development/python-modules/pystemd/default.nix b/pkgs/development/python-modules/pystemd/default.nix
index b193fb80a5f0..210132ca92ca 100644
--- a/pkgs/development/python-modules/pystemd/default.nix
+++ b/pkgs/development/python-modules/pystemd/default.nix
@@ -50,6 +50,7 @@ buildPythonPackage rec {
 
   disabledTestPaths = [
     "test_version.py" # Requires cstq which is not in nixpkgs
+    "test_pickle.py" # fails with "Could not open a bus to DBus"
   ];
 
   pythonImportsCheck = [ "pystemd" ];