diff --git a/pkgs/development/interpreters/python/cpython/default.nix b/pkgs/development/interpreters/python/cpython/default.nix
index dd569db15358..828f729a735a 100644
--- a/pkgs/development/interpreters/python/cpython/default.nix
+++ b/pkgs/development/interpreters/python/cpython/default.nix
@@ -455,6 +455,10 @@ in with passthru; stdenv.mkDerivation (finalAttrs: {
     "ac_cv_func_lchmod=no"
   ] ++ optionals static [
     "LDFLAGS=-static"
+    "MODULE_BUILDTYPE=static"
+  ] ++ optionals (stdenv.hostPlatform.isStatic && stdenv.hostPlatform.isMusl) [
+    # dlopen is a no-op in static musl builds, and since we build everything without -fPIC it's better not to pretend.
+    "ac_cv_func_dlopen=no"
   ];
 
   preConfigure = ''