diff --git a/pkgs/applications/networking/mumble/default.nix b/pkgs/applications/networking/mumble/default.nix
index cab3e4774bee..2b85dcdf17d1 100644
--- a/pkgs/applications/networking/mumble/default.nix
+++ b/pkgs/applications/networking/mumble/default.nix
@@ -10,8 +10,8 @@
   boost,
   libopus,
   libsndfile,
+  speexdsp,
   protobuf,
-  speex,
   libcap,
   alsa-lib,
   python3,
@@ -22,16 +22,21 @@
   libogg,
   libvorbis,
   stdenv_32bit,
+  alsaSupport ? stdenv.hostPlatform.isLinux,
   iceSupport ? true,
   zeroc-ice,
   jackSupport ? false,
   libjack2,
-  pipewireSupport ? true,
+  pipewireSupport ? stdenv.hostPlatform.isLinux,
   pipewire,
   pulseSupport ? true,
   libpulseaudio,
   speechdSupport ? false,
   speechd-minimal,
+  microsoft-gsl,
+  nlohmann_json,
+  xar,
+  makeWrapper,
 }:
 
 let
@@ -52,18 +57,24 @@ let
           qt5.qttools
         ] ++ (overrides.nativeBuildInputs or [ ]);
 
-        buildInputs = [
-          avahi
-          boost
-          poco
-          protobuf
-        ] ++ (overrides.buildInputs or [ ]);
+        buildInputs =
+          [
+            boost
+            poco
+            protobuf
+            microsoft-gsl
+            nlohmann_json
+          ]
+          ++ lib.optionals stdenv.hostPlatform.isLinux [ avahi ]
+          ++ (overrides.buildInputs or [ ]);
 
         cmakeFlags = [
           "-D g15=OFF"
           "-D CMAKE_CXX_STANDARD=17" # protobuf >22 requires C++ 17
           "-D BUILD_NUMBER=${lib.versions.patch source.version}"
-        ] ++ (overrides.configureFlags or [ ]);
+          "-D bundled-gsl=OFF"
+          "-D bundled-json=OFF"
+        ] ++ (overrides.cmakeFlags or [ ]);
 
         preConfigure = ''
           patchShebangs scripts
@@ -79,7 +90,7 @@ let
             felixsinger
             lilacious
           ];
-          platforms = platforms.linux;
+          platforms = platforms.linux ++ (overrides.platforms or [ ]);
         };
       }
     );
@@ -89,7 +100,13 @@ let
     generic {
       type = "mumble";
 
-      nativeBuildInputs = [ qt5.qttools ];
+      platforms = lib.platforms.darwin;
+      nativeBuildInputs =
+        [ qt5.qttools ]
+        ++ lib.optionals stdenv.hostPlatform.isDarwin [
+          makeWrapper
+        ];
+
       buildInputs =
         [
           flac
@@ -97,36 +114,71 @@ let
           libopus
           libsndfile
           libvorbis
+          speexdsp
           qt5.qtsvg
           rnnoise
-          speex
         ]
-        ++ lib.optional (!jackSupport) alsa-lib
+        ++ lib.optional (!jackSupport && alsaSupport) alsa-lib
         ++ lib.optional jackSupport libjack2
         ++ lib.optional speechdSupport speechd-minimal
         ++ lib.optional pulseSupport libpulseaudio
-        ++ lib.optional pipewireSupport pipewire;
+        ++ lib.optional pipewireSupport pipewire
+        ++ lib.optionals stdenv.hostPlatform.isDarwin [
+          xar
+        ];
 
-      configureFlags =
-        [
-          "-D server=OFF"
-          "-D bundled-celt=ON"
-          "-D bundled-opus=OFF"
-          "-D bundled-speex=OFF"
-          "-D bundle-qt-translations=OFF"
-          "-D update=OFF"
-          "-D overlay-xcompile=OFF"
-          "-D oss=OFF"
-          "-D warnings-as-errors=OFF" # conversion error workaround
-        ]
-        ++ lib.optional (!speechdSupport) "-D speechd=OFF"
-        ++ lib.optional (!pulseSupport) "-D pulseaudio=OFF"
-        ++ lib.optional (!pipewireSupport) "-D pipewire=OFF"
-        ++ lib.optional jackSupport "-D alsa=OFF -D jackaudio=ON";
+      cmakeFlags = [
+        "-D server=OFF"
+        "-D bundled-speex=OFF"
+        "-D bundle-qt-translations=OFF"
+        "-D update=OFF"
+        "-D overlay-xcompile=OFF"
+        "-D oss=OFF"
+        "-D warnings-as-errors=OFF" # conversion error workaround
+        # building the overlay on darwin does not work in nipxkgs (yet)
+        # also see the patch below to disable scripts the build option misses
+        # see https://github.com/mumble-voip/mumble/issues/6816
+        (lib.cmakeBool "overlay" (!stdenv.hostPlatform.isDarwin))
+        (lib.cmakeBool "speechd" speechdSupport)
+        (lib.cmakeBool "pulseaudio" pulseSupport)
+        (lib.cmakeBool "pipewire" pipewireSupport)
+        (lib.cmakeBool "jackaudio" jackSupport)
+        (lib.cmakeBool "alsa" (!jackSupport && alsaSupport))
+      ];
 
       env.NIX_CFLAGS_COMPILE = lib.optionalString speechdSupport "-I${speechd-minimal}/include/speech-dispatcher";
 
-      postFixup = ''
+      patches = [
+        ./disable-overlay-build.patch
+        ./fix-plugin-copy.patch
+        # Can be removed before the next update of Mumble, as that fix was upstreamed
+        # fix version display in MacOS Finder
+        (fetchpatch {
+          url = "https://github.com/mumble-voip/mumble/commit/fbd21bd422367bed19f801bf278562f567cbb8b7.patch";
+          sha256 = "sha256-qFhC2j/cOWzAhs+KTccDIdcgFqfr4y4VLjHiK458Ucs=";
+        })
+      ];
+
+      postInstall = lib.optionalString stdenv.hostPlatform.isDarwin ''
+        # The build erraneously marks the *.dylib as executable
+        # which causes the qt-hook to wrap it, which then prevents the app from loading it
+        chmod -x $out/lib/mumble/plugins/*.dylib
+
+        # Post-processing for the app bundle
+        $NIX_BUILD_TOP/source/macx/scripts/osxdist.py \
+          --source-dir=$NIX_BUILD_TOP/source/ \
+          --binary-dir=$out \
+          --only-appbundle \
+          --version "${source.version}"
+
+        mkdir -p $out/Applications $out/bin
+        mv $out/Mumble.app $out/Applications/Mumble.app
+
+        # ensure that the app can be started from the shell
+        makeWrapper $out/Applications/Mumble.app/Contents/MacOS/mumble $out/bin/mumble
+      '';
+
+      postFixup = lib.optionalString stdenv.hostPlatform.isLinux ''
         wrapProgram $out/bin/mumble \
           --prefix LD_LIBRARY_PATH : "${
             lib.makeLibraryPath (
@@ -134,6 +186,7 @@ let
             )
           }"
       '';
+
     } source;
 
   server =
@@ -141,14 +194,13 @@ let
     generic {
       type = "murmur";
 
-      configureFlags =
+      cmakeFlags =
         [
           "-D client=OFF"
+          (lib.cmakeBool "ice" iceSupport)
         ]
-        ++ lib.optional (!iceSupport) "-D ice=OFF"
         ++ lib.optionals iceSupport [
           "-D Ice_HOME=${lib.getDev zeroc-ice};${lib.getLib zeroc-ice}"
-          "-D CMAKE_PREFIX_PATH=${lib.getDev zeroc-ice};${lib.getLib zeroc-ice}"
           "-D Ice_SLICE_DIR=${lib.getDev zeroc-ice}/share/ice/slice"
         ];
 
@@ -161,7 +213,7 @@ let
       stdenv = stdenv_32bit;
       type = "mumble-overlay";
 
-      configureFlags = [
+      cmakeFlags = [
         "-D server=OFF"
         "-D client=OFF"
         "-D overlay=ON"
diff --git a/pkgs/applications/networking/mumble/disable-overlay-build.patch b/pkgs/applications/networking/mumble/disable-overlay-build.patch
new file mode 100644
index 000000000000..9d2aff0d8da0
--- /dev/null
+++ b/pkgs/applications/networking/mumble/disable-overlay-build.patch
@@ -0,0 +1,21 @@
+diff --git a/macx/scripts/osxdist.py b/macx/scripts/osxdist.py
+index bdc7fcbd2..2114caf37 100755
+--- a/macx/scripts/osxdist.py
++++ b/macx/scripts/osxdist.py
+@@ -128,7 +128,7 @@ class AppBundle(object):
+ 				shutil.copy(rsrc, os.path.join(rsrcpath, b))
+
+ 		# Extras
+-		shutil.copy(os.path.join(options.binary_dir, 'MumbleOverlay.pkg'), os.path.join(rsrcpath, 'MumbleOverlay.pkg'))
++		# shutil.copy(os.path.join(options.binary_dir, 'MumbleOverlay.pkg'), os.path.join(rsrcpath, 'MumbleOverlay.pkg'))
+
+ 	def copy_codecs(self):
+ 		'''
+@@ -275,7 +276,7 @@ def package_client():
+ 		title = 'Mumble %s' % ver
+
+ 	# Fix overlay installer package
+-	create_overlay_package()
++	# create_overlay_package()
+ 	if options.only_overlay:
+ 		sys.exit(0)
diff --git a/pkgs/applications/networking/mumble/fix-plugin-copy.patch b/pkgs/applications/networking/mumble/fix-plugin-copy.patch
new file mode 100644
index 000000000000..e8c503944b42
--- /dev/null
+++ b/pkgs/applications/networking/mumble/fix-plugin-copy.patch
@@ -0,0 +1,13 @@
+diff --git a/macx/scripts/osxdist.py b/macx/scripts/osxdist.py
+index bdc7fcbd2..2114caf37 100755
+--- a/macx/scripts/osxdist.py
++++ b/macx/scripts/osxdist.py
+@@ -151,7 +151,7 @@ class AppBundle(object):
+ 		dst = os.path.join(self.bundle, 'Contents', 'Plugins')
+ 		if not os.path.exists(dst):
+ 			os.makedirs(dst)
+-		for plugin in glob.glob(os.path.join(options.binary_dir, 'plugins') + '/*.dylib'):
++		for plugin in glob.glob(os.path.join(options.binary_dir, 'lib/mumble/plugins') + '/*.dylib'):
+ 			shutil.copy(plugin, dst)
+
+ 	def update_plist(self):