diff --git a/nixos/doc/manual/release-notes/rl-2605.section.md b/nixos/doc/manual/release-notes/rl-2605.section.md
index a81de0fdb95e..576f3c6db4c4 100644
--- a/nixos/doc/manual/release-notes/rl-2605.section.md
+++ b/nixos/doc/manual/release-notes/rl-2605.section.md
@@ -206,6 +206,8 @@ of pulling the upstream container image from Docker Hub. If you want the old beh
 
 - `rocmPackages_6` has been removed. `rocmPackages` has been updated to ROCm 7.x. Out of tree packages may rely on obsolete hipblas APIs or compile time constant warp size and need to be updated.
 
+- `mysql80` has been removed. Please update to `mysql84` or `mariadb`. See the [upgrade guide](https://mariadb.com/kb/en/upgrading-from-mysql-to-mariadb/) for more information.
+
 - `services.prometheus.exporters.rspamd` has been removed. It relied on the Rspamd /stat endpoint via the JSON exporter. You can use the Rspamd [/metrics](https://docs.rspamd.com/developers/protocol#controller-http-endpoints) endpoint directly instead.
 
 - The Bash implementation of the `nixos-rebuild` program is removed. All switchable systems now use the Python rewrite. Any prior usage of `system.rebuild.enableNg` must now be removed. If you have any outstanding issues with the new implementation, please open an issue on GitHub.
diff --git a/nixos/modules/services/databases/mysql.nix b/nixos/modules/services/databases/mysql.nix
index 176c3fd4548c..73f8644b2d36 100644
--- a/nixos/modules/services/databases/mysql.nix
+++ b/nixos/modules/services/databases/mysql.nix
@@ -9,7 +9,7 @@ let
   cfg = config.services.mysql;
 
   isMariaDB = lib.getName cfg.package == lib.getName pkgs.mariadb;
-  isOracle = lib.getName cfg.package == lib.getName pkgs.mysql80;
+  isOracle = lib.getName cfg.package == lib.getName pkgs.mysql84;
   # Oracle MySQL has supported "notify" service type since 8.0
   hasNotify = isMariaDB || (isOracle && lib.versionAtLeast cfg.package.version "8.0");
 
diff --git a/nixos/modules/services/web-apps/keycloak.nix b/nixos/modules/services/web-apps/keycloak.nix
index 31ee97320492..1be7f974c687 100644
--- a/nixos/modules/services/web-apps/keycloak.nix
+++ b/nixos/modules/services/web-apps/keycloak.nix
@@ -802,7 +802,7 @@ in
       services.mysql.enable = mkDefault createLocalMySQL;
       services.mysql.package =
         let
-          dbPkg = if cfg.database.type == "mariadb" then pkgs.mariadb else pkgs.mysql80;
+          dbPkg = if cfg.database.type == "mariadb" then pkgs.mariadb else pkgs.mysql84;
         in
         mkIf createLocalMySQL (mkDefault dbPkg);
     };
diff --git a/nixos/tests/mysql/common.nix b/nixos/tests/mysql/common.nix
index 17e961021f14..04be129482fe 100644
--- a/nixos/tests/mysql/common.nix
+++ b/nixos/tests/mysql/common.nix
@@ -4,7 +4,7 @@
     import ../../../pkgs/servers/sql/mariadb pkgs
   );
   mysqlPackages = {
-    inherit (pkgs) mysql80;
+    inherit (pkgs) mysql84;
   };
   perconaPackages = {
     inherit (pkgs) percona-server_8_0 percona-server_8_4;
diff --git a/pkgs/by-name/li/libcbor/package.nix b/pkgs/by-name/li/libcbor/package.nix
index c2445e7d8965..31ad8ed2fbd1 100644
--- a/pkgs/by-name/li/libcbor/package.nix
+++ b/pkgs/by-name/li/libcbor/package.nix
@@ -7,7 +7,7 @@
 
   # for passthru.tests
   libfido2,
-  mysql80,
+  mysql84,
   openssh,
   systemd,
 }:
@@ -50,7 +50,7 @@ stdenv.mkDerivation (finalAttrs: {
   nativeCheckInputs = [ cmocka ];
 
   passthru.tests = {
-    inherit libfido2 mysql80;
+    inherit libfido2 mysql84;
     openssh = (openssh.override { withFIDO = true; });
     systemd = (
       systemd.override {
diff --git a/pkgs/by-name/li/libmysqlconnectorcpp/package.nix b/pkgs/by-name/li/libmysqlconnectorcpp/package.nix
index 5ea9bff13894..3caf6b592b1f 100644
--- a/pkgs/by-name/li/libmysqlconnectorcpp/package.nix
+++ b/pkgs/by-name/li/libmysqlconnectorcpp/package.nix
@@ -5,7 +5,7 @@
   cmake,
   boost,
   openssl,
-  mysql80,
+  mysql84,
 }:
 
 stdenv.mkDerivation (finalAttrs: {
@@ -26,13 +26,13 @@ stdenv.mkDerivation (finalAttrs: {
 
   nativeBuildInputs = [
     cmake
-    mysql80
+    mysql84
   ];
 
   buildInputs = [
     boost
     openssl
-    mysql80
+    mysql84
   ];
 
   strictDeps = true;
diff --git a/pkgs/by-name/my/mysql-workbench/package.nix b/pkgs/by-name/my/mysql-workbench/package.nix
index f0217144bb0c..63ac0e07f947 100644
--- a/pkgs/by-name/my/mysql-workbench/package.nix
+++ b/pkgs/by-name/my/mysql-workbench/package.nix
@@ -20,7 +20,7 @@
   python3Packages,
 
   cairo,
-  mysql80,
+  mysql84,
   libiodbc,
   proj,
 
@@ -41,7 +41,7 @@
 }:
 
 let
-  mysql = mysql80;
+  mysql = mysql84;
   gdal' = gdal.override { libmysqlclient = mysql; };
   antlr = antlr4_13;
 
diff --git a/pkgs/by-name/sq/sqlite3-to-mysql/package.nix b/pkgs/by-name/sq/sqlite3-to-mysql/package.nix
index 8ff3ff9c4542..1cedbdeef6e5 100644
--- a/pkgs/by-name/sq/sqlite3-to-mysql/package.nix
+++ b/pkgs/by-name/sq/sqlite3-to-mysql/package.nix
@@ -5,7 +5,7 @@
   nixosTests,
   testers,
   sqlite3-to-mysql,
-  mysql80,
+  mysql84,
 }:
 
 python3Packages.buildPythonApplication (finalAttrs: {
@@ -37,7 +37,7 @@ python3Packages.buildPythonApplication (finalAttrs: {
     tabulate
     unidecode
     packaging
-    mysql80
+    mysql84
     python-dateutil
     sqlglot
   ];
diff --git a/pkgs/development/python-modules/mysql-connector/default.nix b/pkgs/development/python-modules/mysql-connector/default.nix
index 87ee1887ed02..e97df02712ac 100644
--- a/pkgs/development/python-modules/mysql-connector/default.nix
+++ b/pkgs/development/python-modules/mysql-connector/default.nix
@@ -4,7 +4,7 @@
   dnspython,
   fetchFromGitHub,
   protobuf,
-  mysql80,
+  mysql84,
   openssl,
   pkgs,
 }:
@@ -15,11 +15,11 @@ buildPythonPackage rec {
   format = "setuptools";
 
   setupPyBuildFlags = [
-    "--with-mysql-capi=${mysql80}"
+    "--with-mysql-capi=${mysql84}"
     "--with-openssl-include-dir=${openssl.dev}/include"
     "--with-openssl-lib-dir=${lib.getLib openssl}/lib"
     "-L"
-    "${lib.getLib pkgs.zstd}/lib:${lib.getLib mysql80}/lib"
+    "${lib.getLib pkgs.zstd}/lib:${lib.getLib mysql84}/lib"
   ];
 
   src = fetchFromGitHub {
@@ -40,14 +40,18 @@ buildPythonPackage rec {
     ./0001-Revert-Fix-MacOS-wheels-platform-tag.patch
   ];
 
-  nativeBuildInputs = [ mysql80 ];
+  nativeBuildInputs = [ mysql84 ];
+
+  buildInputs = [
+    mysql84
+    openssl
+    pkgs.zlib
+    pkgs.zstd
+  ];
 
   propagatedBuildInputs = [
     dnspython
     protobuf
-    mysql80
-    openssl
-    pkgs.zstd
   ];
 
   pythonImportsCheck = [ "mysql" ];
diff --git a/pkgs/servers/sql/mysql/8.0.x.nix b/pkgs/servers/sql/mysql/8.0.x.nix
deleted file mode 100644
index 868d9b2b9ca3..000000000000
--- a/pkgs/servers/sql/mysql/8.0.x.nix
+++ /dev/null
@@ -1,130 +0,0 @@
-{
-  lib,
-  stdenv,
-  fetchurl,
-  bison,
-  cmake,
-  pkg-config,
-  boost,
-  icu,
-  libedit,
-  libevent,
-  lz4,
-  ncurses,
-  openssl,
-  protobuf,
-  re2,
-  readline,
-  zlib,
-  zstd,
-  libfido2,
-  numactl,
-  cctools,
-  developer_cmds,
-  libtirpc,
-  rpcsvc-proto,
-  curl,
-  DarwinTools,
-  nixosTests,
-}:
-
-stdenv.mkDerivation (finalAttrs: {
-  pname = "mysql";
-  version = "8.0.45";
-
-  src = fetchurl {
-    url = "https://dev.mysql.com/get/Downloads/MySQL-${lib.versions.majorMinor finalAttrs.version}/mysql-${finalAttrs.version}.tar.gz";
-    hash = "sha256-tDXyLmWMj8k7gWmPo0uaVjJaMEs/Pf+H8n+2dMkKu8s=";
-  };
-
-  nativeBuildInputs = [
-    bison
-    cmake
-    pkg-config
-    protobuf
-  ]
-  ++ lib.optionals (!stdenv.hostPlatform.isDarwin) [ rpcsvc-proto ];
-
-  patches = [
-    ./no-force-outline-atomics.patch # Do not force compilers to turn on -moutline-atomics switch
-  ];
-
-  ## NOTE: MySQL upstream frequently twiddles the invocations of libtool. When updating, you might proactively grep for libtool references.
-  postPatch = lib.optionalString stdenv.hostPlatform.isDarwin ''
-    substituteInPlace cmake/libutils.cmake --replace-fail /usr/bin/libtool ${cctools}/bin/libtool
-    substituteInPlace cmake/os/Darwin.cmake --replace-fail /usr/bin/libtool ${cctools}/bin/libtool
-    substituteInPlace cmake/package_name.cmake --replace-fail "COMMAND sw_vers" "COMMAND ${DarwinTools}/bin/sw_vers"
-  '';
-
-  buildInputs = [
-    boost
-    (curl.override { inherit openssl; })
-    icu
-    libedit
-    libevent
-    lz4
-    ncurses
-    openssl
-    protobuf
-    re2
-    readline
-    zlib
-    zstd
-    libfido2
-  ]
-  ++ lib.optionals stdenv.hostPlatform.isLinux [
-    numactl
-    libtirpc
-  ]
-  ++ lib.optionals stdenv.hostPlatform.isDarwin [
-    developer_cmds
-  ];
-
-  strictDeps = true;
-
-  outputs = [
-    "out"
-    "static"
-  ];
-
-  cmakeFlags = [
-    "-DFORCE_UNSUPPORTED_COMPILER=1" # To configure on Darwin.
-    "-DWITH_ROUTER=OFF" # It may be packaged separately.
-    "-DWITH_SYSTEM_LIBS=ON"
-    "-DWITH_UNIT_TESTS=OFF"
-    "-DMYSQL_UNIX_ADDR=/run/mysqld/mysqld.sock"
-    "-DMYSQL_DATADIR=/var/lib/mysql"
-    "-DINSTALL_INFODIR=share/mysql/docs"
-    "-DINSTALL_MANDIR=share/man"
-    "-DINSTALL_PLUGINDIR=lib/mysql/plugin"
-    "-DINSTALL_INCLUDEDIR=include/mysql"
-    "-DINSTALL_DOCREADMEDIR=share/mysql"
-    "-DINSTALL_SUPPORTFILESDIR=share/mysql"
-    "-DINSTALL_MYSQLSHAREDIR=share/mysql"
-    "-DINSTALL_MYSQLTESTDIR="
-    "-DINSTALL_DOCDIR=share/mysql/docs"
-    "-DINSTALL_SHAREDIR=share/mysql"
-  ];
-
-  postInstall = ''
-    moveToOutput "lib/*.a" $static
-    so=${stdenv.hostPlatform.extensions.sharedLibrary}
-    ln -s libmysqlclient$so $out/lib/libmysqlclient_r$so
-  '';
-
-  passthru = {
-    client = finalAttrs.finalPackage;
-    connector-c = finalAttrs.finalPackage;
-    server = finalAttrs.finalPackage;
-    mysqlVersion = lib.versions.majorMinor finalAttrs.version;
-    tests = nixosTests.mysql.mysql80;
-  };
-
-  meta = {
-    homepage = "https://www.mysql.com/";
-    description = "World's most popular open source database";
-    license = lib.licenses.gpl2Only;
-    maintainers = [ ];
-    platforms = lib.platforms.unix;
-  };
-})
diff --git a/pkgs/servers/sql/mysql/no-force-outline-atomics.patch b/pkgs/servers/sql/mysql/no-force-outline-atomics.patch
deleted file mode 100644
index a716a4f7f481..000000000000
--- a/pkgs/servers/sql/mysql/no-force-outline-atomics.patch
+++ /dev/null
@@ -1,24 +0,0 @@
-diff --git a/CMakeLists.txt b/CMakeLists.txt
-index 727d66011f9..acae1aada57 100644
---- a/CMakeLists.txt
-+++ b/CMakeLists.txt
-@@ -1338,19 +1338,6 @@ IF(UNIX AND MY_COMPILER_IS_GNU_OR_CLANG
-   ENDIF()
- ENDIF()
- 
--# For aarch64 some sub-architectures support LSE atomics and some don't. Thus,
--# compiling for the common denominator (-march=armv8-a) means LSE is not used.
--# The -moutline-atomics switch enables run-time detection of LSE support.
--# There are compilers (gcc 9.3.1 for example) which support this switch, but
--# do not enable it by default, even though it seems to help. So, we force it.
--IF(CMAKE_SYSTEM_PROCESSOR STREQUAL "aarch64")
--  MY_CHECK_CXX_COMPILER_FLAG( "-moutline-atomics" HAVE_OUTLINE_ATOMICS)
--  IF(HAVE_OUTLINE_ATOMICS)
--    STRING_APPEND(CMAKE_C_FLAGS   " -moutline-atomics")
--    STRING_APPEND(CMAKE_CXX_FLAGS " -moutline-atomics")
--  ENDIF()
--ENDIF()
--
- IF(LINUX)
-   OPTION(LINK_RANDOMIZE "Randomize the order of all symbols in the binary" OFF)
-   SET(LINK_RANDOMIZE_SEED "mysql"
diff --git a/pkgs/top-level/aliases.nix b/pkgs/top-level/aliases.nix
index a827d8e45ddc..1ebdd42840d1 100644
--- a/pkgs/top-level/aliases.nix
+++ b/pkgs/top-level/aliases.nix
@@ -1398,6 +1398,7 @@ mapAliases {
   mutter46 = throw "'mutter46' has been removed, no longer used by Pantheon"; # Added 2026-01-24
   muzika = throw "muzika was discontinued upstream in november 2024"; # Added 2025-12-15;
   mx-puppet-discord = throw "mx-puppet-discord was removed since the packaging was unmaintained and was the sole user of sha1 hashes in nixpkgs"; # Added 2025-07-24
+  mysql80 = throw "'mysql80' reached end of life on 2026-04-30 and has been removed."; # Added 2026-04-08
   mysql-client = throw "mysql-client has been replaced by mariadb.client"; # Converted to throw 2025-10-26
   n98-magerun = throw "n98-magerun doesn't support new PHP newer than 8.1"; # Added 2025-10-03
   nagiosPluginsOfficial = throw "'nagiosPluginsOfficial' has been renamed to/replaced by 'monitoring-plugins'"; # Converted to throw 2025-10-27
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 11eb191e29f0..d2b9010caaff 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -8330,13 +8330,6 @@ with pkgs;
     boost = boost179.override { enableShared = false; };
   };
 
-  mysql80 = callPackage ../servers/sql/mysql/8.0.x.nix {
-    inherit (darwin) developer_cmds DarwinTools;
-    boost = boost177; # Configure checks for specific version.
-    icu = icu69;
-    protobuf = protobuf_21;
-  };
-
   mssql_jdbc = callPackage ../servers/sql/mssql/jdbc { };
   jtds_jdbc = callPackage ../servers/sql/mssql/jdbc/jtds.nix { };
 
diff --git a/pkgs/top-level/perl-packages.nix b/pkgs/top-level/perl-packages.nix
index 66e94648bc2a..14552ea229ec 100644
--- a/pkgs/top-level/perl-packages.nix
+++ b/pkgs/top-level/perl-packages.nix
@@ -9818,7 +9818,7 @@ with self;
     };
 
     nativeBuildInputs = [
-      pkgs.mysql80 # for mysql_config
+      pkgs.mysql84 # for mysql_config
     ];
     buildInputs = [
       DevelChecklib
@@ -9828,6 +9828,7 @@ with self;
       pkgs.libmysqlconnectorcpp
       pkgs.libxcrypt
       pkgs.openssl
+      pkgs.zlib
       pkgs.zstd
     ];
     propagatedBuildInputs = [ DBI ];