diff --git a/pkgs/development/python-modules/cassandra-driver/default.nix b/pkgs/development/python-modules/cassandra-driver/default.nix
index c850c6a89dd0..9548bd1214d8 100644
--- a/pkgs/development/python-modules/cassandra-driver/default.nix
+++ b/pkgs/development/python-modules/cassandra-driver/default.nix
@@ -3,33 +3,31 @@
   stdenv,
   buildPythonPackage,
   cryptography,
-  cython_0,
+  cython,
   eventlet,
   fetchFromGitHub,
+  fetchpatch2,
   geomet,
   gevent,
   gremlinpython,
   iana-etc,
   libev,
   libredirect,
-  mock,
-  nose,
   pytestCheckHook,
-  pythonOlder,
   pytz,
   pyyaml,
   scales,
   six,
   sure,
   twisted,
+  setuptools,
+  distutils,
 }:
 
 buildPythonPackage rec {
   pname = "cassandra-driver";
   version = "3.29.1";
-  format = "setuptools";
-
-  disabled = pythonOlder "3.7";
+  pyproject = true;
 
   src = fetchFromGitHub {
     owner = "datastax";
@@ -38,29 +36,53 @@ buildPythonPackage rec {
     hash = "sha256-pnNm5Pd5k4bt+s3GrUUDWRpSdqNSM89GiX8DZKYzW1E=";
   };
 
-  postPatch = ''
-    substituteInPlace setup.py \
-      --replace 'geomet>=0.1,<0.3' 'geomet'
-  '';
+  patches = [
+    # https://github.com/datastax/python-driver/pull/1201
+    # Also needed for below patch to apply
+    (fetchpatch2 {
+      name = "remove-mock-dependency.patch";
+      url = "https://github.com/datastax/python-driver/commit/9aca00be33d96559f0eabc1c8a26bb439dcebbd7.patch";
+      hash = "sha256-ZN95V8ebbjahzqBat2oKBJLfu0fqbWMvAu0DzfVGw8I=";
+    })
+    # https://github.com/datastax/python-driver/pull/1215
+    (fetchpatch2 {
+      name = "convert-to-pytest.patch";
+      url = "https://github.com/datastax/python-driver/commit/9952e2ab22c7e034b96cc89330791d73c221546b.patch";
+      hash = "sha256-xa2aV6drBcgkQT05kt44vwupg3oMHLbcbZSQ7EHKnko=";
+    })
+    # https://github.com/datastax/python-driver/pull/1195
+    (fetchpatch2 {
+      name = "remove-assertRaisesRegexp.patch";
+      url = "https://github.com/datastax/python-driver/commit/622523b83971e8a181eb4853b7d877420c0351ef.patch";
+      hash = "sha256-Q8pRhHBLKyenMfrITf8kDv3BbsSCDAmVisTr4jSAIvA=";
+    })
+  ];
 
-  nativeBuildInputs = [ cython_0 ];
+  pythonRelaxDeps = [ "geomet" ];
+
+  build-system = [
+    distutils
+    setuptools
+    cython
+  ];
 
   buildInputs = [ libev ];
 
-  propagatedBuildInputs = [
+  dependencies = [
     six
     geomet
   ];
 
   nativeCheckInputs = [
     pytestCheckHook
-    mock
-    nose
     pytz
     pyyaml
     sure
   ] ++ lib.flatten (lib.attrValues passthru.optional-dependencies);
 
+  # This is used to determine the version of cython that can be used
+  CASS_DRIVER_ALLOWED_CYTHON_VERSION = cython.version;
+
   # Make /etc/protocols accessible to allow socket.getprotobyname('tcp') in sandbox,
   # also /etc/resolv.conf is referenced by some tests
   preCheck =
@@ -92,6 +114,8 @@ buildPythonPackage rec {
   disabledTestPaths = [
     # requires puresasl
     "tests/unit/advanced/test_auth.py"
+    # Uses asyncore, which is deprecated in python 3.12+
+    "tests/unit/io/test_asyncorereactor.py"
   ];
 
   disabledTests = [
@@ -112,11 +136,11 @@ buildPythonPackage rec {
     twisted = [ twisted ];
   };
 
-  meta = with lib; {
+  meta = {
     description = "Python client driver for Apache Cassandra";
     homepage = "http://datastax.github.io/python-driver";
     changelog = "https://github.com/datastax/python-driver/blob/${version}/CHANGELOG.rst";
-    license = licenses.asl20;
-    maintainers = with maintainers; [ ris ];
+    license = lib.licenses.asl20;
+    maintainers = with lib.maintainers; [ ris ];
   };
 }