diff --git a/pkgs/development/python-modules/ome-zarr/default.nix b/pkgs/development/python-modules/ome-zarr/default.nix
index 67a14ed7a03a..78f854f744b7 100644
--- a/pkgs/development/python-modules/ome-zarr/default.nix
+++ b/pkgs/development/python-modules/ome-zarr/default.nix
@@ -57,6 +57,11 @@ buildPythonPackage rec {
   disabledTests = [
     # attempts to access network
     "test_s3_info"
+
+    # AssertionError: assert {'blocksize':... 'blosc', ...} == {'blocksize':... 'blosc', ...}
+    # comp {'id': 'blosc', 'cname': 'lz4', 'clevel': 5, 'shuffle': 1, 'blocksize': 0}
+    "test_default_compression"
+    "test_write_image_compressed"
   ];
 
   disabledTestPaths = [