diff --git a/pkgs/by-name/tu/tup/package.nix b/pkgs/by-name/tu/tup/package.nix
index 4bccae8ee432..88d66c069e4b 100644
--- a/pkgs/by-name/tu/tup/package.nix
+++ b/pkgs/by-name/tu/tup/package.nix
@@ -38,7 +38,19 @@ stdenv.mkDerivation rec {
   patches = [ ./fusermount-setuid.patch ];
 
   configurePhase = ''
-    substituteInPlace  src/tup/link.sh --replace '`git describe' '`echo ${version}'
+    substituteInPlace  src/tup/link.sh --replace-fail '`git describe' '`echo ${version}'
+
+    for path in Tupfile build.sh src/tup/server/Tupfile ; do
+      substituteInPlace  $path  --replace-fail "pkg-config" "${stdenv.cc.targetPrefix}pkg-config"
+    done
+
+    # Replace "pcre2-config --libs8" => "pkg-config libpcre2-8 --libs".
+    #
+    # There is prefixed pkg-config for cross-compilation, but no prefixed "pcre2-config".
+    for path in Tupfile Tuprules.tup ; do
+      substituteInPlace  $path --replace-fail "pcre2-config" "${stdenv.cc.targetPrefix}pkg-config libpcre2-8 "
+    done
+    substituteInPlace  Tupfile --replace-fail "--libs8" "--libs"
 
     cat << EOF > tup.config
     CONFIG_CC=${stdenv.cc.targetPrefix}cc