diff --git a/pkgs/development/python-modules/uvloop/default.nix b/pkgs/development/python-modules/uvloop/default.nix
index 125850a080f3..a762ec55ee36 100644
--- a/pkgs/development/python-modules/uvloop/default.nix
+++ b/pkgs/development/python-modules/uvloop/default.nix
@@ -48,6 +48,9 @@ buildPythonPackage rec {
     # test gets stuck in epoll_pwait on hydras aarch64 builders
     # https://github.com/MagicStack/uvloop/issues/412
     "--deselect" "tests/test_tcp.py::Test_AIO_TCPSSL::test_remote_shutdown_receives_trailing_data"
+  ] ++ lib.optionals (stdenv.isDarwin && stdenv.isAarch64) [
+    # Flaky test: https://github.com/MagicStack/uvloop/issues/412
+    "--deselect" "tests/test_tcp.py::Test_UV_TCPSSL::test_shutdown_timeout_handler_not_set"
   ];
 
   disabledTestPaths = [