diff --git a/pkgs/development/python-modules/pyside2/default.nix b/pkgs/development/python-modules/pyside2/default.nix
index 1b1f54874376..be281be33c4e 100644
--- a/pkgs/development/python-modules/pyside2/default.nix
+++ b/pkgs/development/python-modules/pyside2/default.nix
@@ -1,4 +1,6 @@
 { python
+, pythonAtLeast
+, disabledIf
 , fetchurl
 , lib
 , stdenv
@@ -9,6 +11,10 @@
 , shiboken2
 }:
 
+# Only build when Python<=3.10
+# See https://bugreports.qt.io/browse/PYSIDE-1864
+# "There are no plans to support Python versions > 3.10 in the 5.15 branch."
+disabledIf (pythonAtLeast "3.11") (
 stdenv.mkDerivation rec {
   pname = "pyside2";
   version = "5.15.5";
@@ -74,4 +80,4 @@ stdenv.mkDerivation rec {
     homepage = "https://wiki.qt.io/Qt_for_Python";
     maintainers = with maintainers; [ gebner ];
   };
-}
+})