diff --git a/pkgs/development/python-modules/mypy-boto3/default.nix b/pkgs/development/python-modules/mypy-boto3/default.nix
index 6570a45fde0f..1ff4118edf43 100644
--- a/pkgs/development/python-modules/mypy-boto3/default.nix
+++ b/pkgs/development/python-modules/mypy-boto3/default.nix
@@ -590,8 +590,8 @@ in
       "sha256-+DDeD9YWo98meLZU2Mzu5AE0S7HFg6kfxeUWUh9XcQA=";
 
   mypy-boto3-guardduty =
-    buildMypyBoto3Package "guardduty" "1.43.35"
-      "sha256-L0DBDIfXuZjJZRA63rZRukaXcPBHzt+H4AzeNc67xaw=";
+    buildMypyBoto3Package "guardduty" "1.43.45"
+      "sha256-i/5xOzymGSnyYznSODZCBgCZM1JRXz7R9VKU71J9yNs=";
 
   mypy-boto3-health =
     buildMypyBoto3Package "health" "1.43.0"