diff --git a/pkgs/development/python-modules/rdkit/default.nix b/pkgs/development/python-modules/rdkit/default.nix
index 07c18b5463a8..ee5de87d3305 100644
--- a/pkgs/development/python-modules/rdkit/default.nix
+++ b/pkgs/development/python-modules/rdkit/default.nix
@@ -1,4 +1,5 @@
 { lib
+, stdenv
 , buildPythonPackage
 , fetchFromGitHub
 , cmake
@@ -15,6 +16,7 @@
 , numpy
 , pandas
 , pillow
+, memorymappingHook
 }:
 let
   external = {
@@ -82,6 +84,8 @@ buildPythonPackage rec {
   buildInputs = [
     boost
     cairo
+  ] ++ lib.optionals (stdenv.system == "x86_64-darwin") [
+    memorymappingHook
   ];
 
   propagatedBuildInputs = [