diff --git a/pkgs/development/libraries/SDL2/default.nix b/pkgs/development/libraries/SDL2/default.nix
index 5f3d42b4da37..40fe1c42d7a6 100644
--- a/pkgs/development/libraries/SDL2/default.nix
+++ b/pkgs/development/libraries/SDL2/default.nix
@@ -42,9 +42,14 @@ stdenv.mkDerivation rec {
     substituteInPlace include/SDL_opengl_glext.h \
       --replace "typedef ptrdiff_t GLsizeiptr;" "typedef signed long int khronos_ssize_t; typedef khronos_ssize_t GLsizeiptr;" \
       --replace "typedef ptrdiff_t GLintptr;" "typedef signed long int khronos_intptr_t; typedef khronos_intptr_t GLintptr;"
+
+    substituteInPlace configure \
+      --replace 'WAYLAND_SCANNER=`$PKG_CONFIG --variable=wayland_scanner wayland-scanner`' 'WAYLAND_SCANNER=`pkg-config --variable=wayland_scanner wayland-scanner`'
   '';
 
-  nativeBuildInputs = [ pkgconfig ];
+  depsBuildBuild = [ pkgconfig ];
+
+  nativeBuildInputs = [ pkgconfig wayland ];
 
   propagatedBuildInputs = dlopenPropagatedBuildInputs;
 
diff --git a/pkgs/development/libraries/avahi/default.nix b/pkgs/development/libraries/avahi/default.nix
index 8568d5dd2ab2..3f36b87af704 100644
--- a/pkgs/development/libraries/avahi/default.nix
+++ b/pkgs/development/libraries/avahi/default.nix
@@ -23,6 +23,11 @@ stdenv.mkDerivation rec {
     sha256 = "0128n7jlshw4bpx0vg8lwj8qwdisjxi7mvniwfafgnkzzrfrpaap";
   };
 
+  prePatch = ''
+    substituteInPlace configure \
+      --replace pkg-config "$PKG_CONFIG"
+  '';
+
   patches = [
     ./no-mkdir-localstatedir.patch
     (fetchpatch {
diff --git a/pkgs/development/libraries/openldap/default.nix b/pkgs/development/libraries/openldap/default.nix
index 56955b88ee4c..b60eb4fbaabd 100644
--- a/pkgs/development/libraries/openldap/default.nix
+++ b/pkgs/development/libraries/openldap/default.nix
@@ -23,7 +23,8 @@ stdenv.mkDerivation rec {
     "STRIP="
     "prefix=$(out)"
     "moduledir=$(out)/lib/modules"
-  ] ++ stdenv.lib.optionals stdenv.isDarwin [ "CC=cc" ];
+    "CC=${stdenv.cc.targetPrefix}cc"
+  ];
 
   configureFlags = [
     "--enable-overlays"
diff --git a/pkgs/development/tools/misc/strace/default.nix b/pkgs/development/tools/misc/strace/default.nix
index 23700a2ddc2d..cbae92dd6d13 100644
--- a/pkgs/development/tools/misc/strace/default.nix
+++ b/pkgs/development/tools/misc/strace/default.nix
@@ -12,9 +12,9 @@ stdenv.mkDerivation rec {
   depsBuildBuild = [ buildPackages.stdenv.cc ];
   nativeBuildInputs = [ perl ];
 
-  buildInputs = stdenv.lib.optional libunwind.supportsHost libunwind; # support -k
+  buildInputs = [ perl.out ] ++ stdenv.lib.optional libunwind.supportsHost libunwind; # support -k
 
-  postPatch = "patchShebangs strace-graph";
+  postPatch = "patchShebangs --host strace-graph";
 
   configureFlags = stdenv.lib.optional (!stdenv.hostPlatform.isx86) "--enable-mpers=check";
 
diff --git a/pkgs/misc/emulators/retroarch/default.nix b/pkgs/misc/emulators/retroarch/default.nix
index a9950a14b4d9..bfc2c338769c 100644
--- a/pkgs/misc/emulators/retroarch/default.nix
+++ b/pkgs/misc/emulators/retroarch/default.nix
@@ -43,9 +43,6 @@ stdenv.mkDerivation rec {
                                               libXdmcp libXext libXxf86vm mesa udev
                                               wayland libxkbcommon ];
 
-  # we use prefix-less pkg-config
-  PKG_CONF_PATH = "pkg-config";
-
   enableParallelBuilding = true;
 
   configureFlags = stdenv.lib.optionals stdenv.isLinux [ "--enable-kms" "--enable-egl" ];
diff --git a/pkgs/os-specific/linux/crda/default.nix b/pkgs/os-specific/linux/crda/default.nix
index 5811e9358b01..137e88cd6e87 100644
--- a/pkgs/os-specific/linux/crda/default.nix
+++ b/pkgs/os-specific/linux/crda/default.nix
@@ -31,7 +31,9 @@ stdenv.mkDerivation rec {
 
   postPatch = ''
     patchShebangs utils/
-    substituteInPlace Makefile --replace ldconfig true
+    substituteInPlace Makefile \
+      --replace ldconfig true \
+      --replace pkg-config $PKG_CONFIG
     sed -i crda.c \
       -e "/\/usr\/.*\/regulatory.bin/d" \
       -e "s|/lib/crda|${wireless-regdb}/lib/crda|g"
diff --git a/pkgs/servers/pulseaudio/default.nix b/pkgs/servers/pulseaudio/default.nix
index e15efd4b47d1..513249cb7ad5 100644
--- a/pkgs/servers/pulseaudio/default.nix
+++ b/pkgs/servers/pulseaudio/default.nix
@@ -61,6 +61,11 @@ stdenv.mkDerivation rec {
       ++ lib.optional zeroconfSupport  avahi
   );
 
+  prePatch = ''
+    substituteInPlace bootstrap.sh \
+      --replace pkg-config $PKG_CONFIG
+  '';
+
   autoreconfPhase = ''
     # Performs an autoreconf
     patchShebangs bootstrap.sh
diff --git a/pkgs/top-level/perl-packages.nix b/pkgs/top-level/perl-packages.nix
index 09869689924a..67fedb2a2fe2 100644
--- a/pkgs/top-level/perl-packages.nix
+++ b/pkgs/top-level/perl-packages.nix
@@ -13822,6 +13822,10 @@ let
       sha256 = "19nf4xn9xhyd0sd2az9iliqldjj0k6ah2dmkyqyvq4rp2d9k5jgb";
     });
 
+    postPatch = ''
+      substituteInPlace Makefile.PL --replace pkg-config $PKG_CONFIG
+    '';
+
     meta = {
       homepage = "http://www.freedesktop.org/wiki/Software/dbus";
       description = "Extension for the DBus bindings";