diff --git a/pkgs/development/libraries/glibc/2.32-master.patch.gz b/pkgs/development/libraries/glibc/2.32-master.patch.gz
deleted file mode 100644
index 8ea998b5bea2..000000000000
Binary files a/pkgs/development/libraries/glibc/2.32-master.patch.gz and /dev/null differ
diff --git a/pkgs/development/libraries/glibc/2.33-master.patch.gz b/pkgs/development/libraries/glibc/2.33-master.patch.gz
new file mode 100644
index 000000000000..610f49d22592
Binary files /dev/null and b/pkgs/development/libraries/glibc/2.33-master.patch.gz differ
diff --git a/pkgs/development/libraries/glibc/common.nix b/pkgs/development/libraries/glibc/common.nix
index 7725a3e4bf2e..3a5da0afc744 100644
--- a/pkgs/development/libraries/glibc/common.nix
+++ b/pkgs/development/libraries/glibc/common.nix
@@ -41,9 +41,9 @@
 } @ args:
 
 let
-  version = "2.32";
-  patchSuffix = "-48";
-  sha256 = "0di848ibffrnwq7g2dvgqrnn4xqhj3h96csn69q4da51ymafl9qn";
+  version = "2.33";
+  patchSuffix = "-45";
+  sha256 = "sha256-LiVWAA4QXb1X8Layoy/yzxc73k8Nhd/8z9i35RoGd/8=";
 in
 
 assert withLinuxHeaders -> linuxHeaders != null;
@@ -60,14 +60,14 @@ stdenv.mkDerivation ({
   patches =
     [
       /* No tarballs for stable upstream branch, only https://sourceware.org/git/glibc.git and using git would complicate bootstrapping.
-          $ git fetch --all -p && git checkout origin/release/2.32/master && git describe
-          glibc-2.32-48-g16949aeaa0
-          $ git show --minimal --reverse glibc-2.32.. | gzip -9n --rsyncable - > 2.32-master.patch.gz
+          $ git fetch --all -p && git checkout origin/release/2.33/master && git describe
+          glibc-2.33-45-g58b90461ae
+          $ git show --minimal --reverse glibc-2.33.. | gzip -9n --rsyncable - > 2.33-master.patch.gz
 
          To compare the archive contents zdiff can be used.
-          $ zdiff -u 2.32-master.patch.gz ../nixpkgs/pkgs/development/libraries/glibc/2.32-master.patch.gz
+          $ zdiff -u 2.33-master.patch.gz ../nixpkgs/pkgs/development/libraries/glibc/2.33-master.patch.gz
        */
-      ./2.32-master.patch.gz
+      ./2.33-master.patch.gz
 
       /* Allow NixOS and Nix to handle the locale-archive. */
       ./nix-locale-archive.patch
diff --git a/pkgs/development/libraries/glibc/dont-use-system-ld-so-cache.patch b/pkgs/development/libraries/glibc/dont-use-system-ld-so-cache.patch
index f84b1049adf8..0e0315aca270 100644
--- a/pkgs/development/libraries/glibc/dont-use-system-ld-so-cache.patch
+++ b/pkgs/development/libraries/glibc/dont-use-system-ld-so-cache.patch
@@ -1,19 +1,8 @@
-diff -Naur glibc-2.27-orig/elf/ldconfig.c glibc-2.27/elf/ldconfig.c
---- glibc-2.27-orig/elf/ldconfig.c	2018-02-01 11:17:18.000000000 -0500
-+++ glibc-2.27/elf/ldconfig.c	2018-02-17 22:43:17.232175182 -0500
-@@ -51,7 +51,7 @@
- #endif
- 
- #ifndef LD_SO_CONF
--# define LD_SO_CONF SYSCONFDIR "/ld.so.conf"
-+# define LD_SO_CONF PREFIX "/etc/ld.so.conf"
- #endif
- 
- /* Get libc version number.  */
-diff -Naur glibc-2.27-orig/elf/Makefile glibc-2.27/elf/Makefile
---- glibc-2.27-orig/elf/Makefile	2018-02-01 11:17:18.000000000 -0500
-+++ glibc-2.27/elf/Makefile	2018-02-17 22:44:50.334006750 -0500
-@@ -559,13 +559,13 @@
+diff --git a/elf/Makefile b/elf/Makefile
+index 5d666b1b..a5017e9c 100644
+--- a/elf/Makefile
++++ b/elf/Makefile
+@@ -669,14 +669,14 @@ $(objpfx)sln: $(sln-modules:%=$(objpfx)%.o)
  
  $(objpfx)ldconfig: $(ldconfig-modules:%=$(objpfx)%.o)
  
@@ -26,16 +15,45 @@ diff -Naur glibc-2.27-orig/elf/Makefile glibc-2.27/elf/Makefile
 -CFLAGS-dl-cache.c += $(SYSCONF-FLAGS)
 -CFLAGS-cache.c += $(SYSCONF-FLAGS)
 -CFLAGS-rtld.c += $(SYSCONF-FLAGS)
+-CFLAGS-dl-usage.c += $(SYSCONF-FLAGS) \
 +CFLAGS-dl-cache.c += $(PREFIX-FLAGS)
 +CFLAGS-cache.c += $(PREFIX-FLAGS)
 +CFLAGS-rtld.c += $(PREFIX-FLAGS)
++CFLAGS-dl-usage.c += $(PREFIX-FLAGS) \
+   -D'RTLD="$(rtlddir)/$(rtld-installed-name)"'
  
  cpp-srcs-left := $(all-rtld-routines:=.os)
- lib := rtld
-diff -Naur glibc-2.27-orig/sysdeps/generic/dl-cache.h glibc-2.27/sysdeps/generic/dl-cache.h
---- glibc-2.27-orig/sysdeps/generic/dl-cache.h	2018-02-01 11:17:18.000000000 -0500
-+++ glibc-2.27/sysdeps/generic/dl-cache.h	2018-02-17 22:45:20.471598816 -0500
-@@ -28,7 +28,7 @@
+diff --git a/elf/dl-diagnostics.c b/elf/dl-diagnostics.c
+index bef224b3..8e166b12 100644
+--- a/elf/dl-diagnostics.c
++++ b/elf/dl-diagnostics.c
+@@ -205,7 +205,7 @@ print_paths (void)
+ {
+   _dl_diagnostics_print_labeled_string ("path.prefix", PREFIX);
+   _dl_diagnostics_print_labeled_string ("path.rtld", RTLD);
+-  _dl_diagnostics_print_labeled_string ("path.sysconfdir", SYSCONFDIR);
++  _dl_diagnostics_print_labeled_string ("path.sysconfdir", PREFIX "/etc");
+
+   unsigned int index = 0;
+   static const char *system_dirs = SYSTEM_DIRS "\0";
+diff --git a/elf/ldconfig.c b/elf/ldconfig.c
+index 28ed637a..6f07b79a 100644
+--- a/elf/ldconfig.c
++++ b/elf/ldconfig.c
+@@ -57,7 +57,7 @@
+ #define TLS_HWCAP_BIT 63
+ 
+ #ifndef LD_SO_CONF
+-# define LD_SO_CONF SYSCONFDIR "/ld.so.conf"
++# define LD_SO_CONF PREFIX "/etc/ld.so.conf"
+ #endif
+ 
+ /* Get libc version number.  */
+diff --git a/sysdeps/generic/dl-cache.h b/sysdeps/generic/dl-cache.h
+index 964d50a4..2224d651 100644
+--- a/sysdeps/generic/dl-cache.h
++++ b/sysdeps/generic/dl-cache.h
+@@ -35,7 +35,7 @@
  #endif
  
  #ifndef LD_SO_CACHE