diff --git a/pkgs/development/python-modules/diffusers/default.nix b/pkgs/development/python-modules/diffusers/default.nix
index 39464efe47fd..19fe676abb64 100644
--- a/pkgs/development/python-modules/diffusers/default.nix
+++ b/pkgs/development/python-modules/diffusers/default.nix
@@ -1,8 +1,9 @@
 { lib
 , stdenv
 , buildPythonPackage
-, fetchFromGitHub
 , pythonOlder
+, fetchFromGitHub
+, fetchpatch
 , writeText
 , setuptools
 , wheel
@@ -35,6 +36,7 @@
 , sentencepiece
 , torchsde
 , transformers
+, pythonAtLeast
 }:
 
 buildPythonPackage rec {
@@ -51,12 +53,26 @@ buildPythonPackage rec {
     hash = "sha256-aRnbU3jN40xaCsoMFyRt1XB+hyIYMJP2b/T1yZho90c=";
   };
 
-  nativeBuildInputs = [
+  patches = [
+    # fix python3.12 build
+    (fetchpatch { # https://github.com/huggingface/diffusers/pull/7455
+      name = "001-remove-distutils.patch";
+      url = "https://github.com/huggingface/diffusers/compare/363699044e365ef977a7646b500402fa585e1b6b...3c67864c5acb30413911730b1ed4a9ad47c0a15c.patch";
+      hash = "sha256-Qyvyp1GyTVXN+A+lA1r2hf887ubTtaUknbKd4r46NZQ=";
+    })
+    (fetchpatch { # https://github.com/huggingface/diffusers/pull/7461
+      name = "002-fix-removed-distutils.patch";
+      url = "https://github.com/huggingface/diffusers/commit/efbbbc38e436a1abb1df41a6eccfd6f9f0333f97.patch";
+      hash = "sha256-scdtpX1RYFFEDHcaMb+gDZSsPafkvnIO/wQlpzrQhLA=";
+    })
+  ];
+
+  build-system = [
     setuptools
     wheel
   ];
 
-  propagatedBuildInputs = [
+  dependencies = [
     filelock
     huggingface-hub
     importlib-metadata
@@ -143,6 +159,10 @@ buildPythonPackage rec {
     "test_model_cpu_offload_forward_pass"
     # tries to run ruff which we have intentionally removed from nativeCheckInputs
     "test_is_copy_consistent"
+  ] ++ lib.optionals (pythonAtLeast "3.12") [
+
+    # RuntimeError: Dynamo is not supported on Python 3.12+
+    "test_from_save_pretrained_dynamo"
   ];
 
   meta = with lib; {
diff --git a/pkgs/development/python-modules/gradio/client.nix b/pkgs/development/python-modules/gradio/client.nix
index 96c293d399c5..bbf4d468ce69 100644
--- a/pkgs/development/python-modules/gradio/client.nix
+++ b/pkgs/development/python-modules/gradio/client.nix
@@ -28,8 +28,8 @@
 
 buildPythonPackage rec {
   pname = "gradio-client";
-  version = "0.14.0";
-  format = "pyproject";
+  version = "0.16.1";
+  pyproject = true;
 
   disabled = pythonOlder "3.8";
 
@@ -37,9 +37,9 @@ buildPythonPackage rec {
   src = fetchFromGitHub {
     owner = "gradio-app";
     repo = "gradio";
-    rev = "refs/tags/@gradio/client@${version}";
+    rev = "refs/tags/gradio_client@${version}";
     sparseCheckout = [ "client/python" ];
-    hash = "sha256-7oC/Z3YUiOFZdv/60q7PkfluV77broRkHgWiY9Vim9Y=";
+    hash = "sha256-SVUm9LrjYG0r3U1yOd3rctxVMYlnAOW+Opqy9c3osnw=";
   };
   prePatch = ''
     cd client/python
@@ -52,7 +52,7 @@ buildPythonPackage rec {
     "websockets"
   ];
 
-  nativeBuildInputs = [
+  build-system = [
     hatchling
     hatch-requirements-txt
     hatch-fancy-pypi-readme
diff --git a/pkgs/development/python-modules/gradio/default.nix b/pkgs/development/python-modules/gradio/default.nix
index 0d4838e372de..7f3a173cf1ae 100644
--- a/pkgs/development/python-modules/gradio/default.nix
+++ b/pkgs/development/python-modules/gradio/default.nix
@@ -62,7 +62,7 @@
 
 buildPythonPackage rec {
   pname = "gradio";
-  version = "4.27.0";
+  version = "4.29.0";
   format = "pyproject";
 
   disabled = pythonOlder "3.7";
@@ -71,7 +71,7 @@ buildPythonPackage rec {
   # and upstream has stopped tagging releases since 3.41.0
   src = fetchPypi {
     inherit pname version;
-    hash = "sha256-617zutFhS8NGO4+fcALH8aKbk+reGC65DNWKVVKiWEw=";
+    hash = "sha256-17KT0b9kBO+xLgIgxfpwjETDoRM4aTJPlJv7HjkJXjo=";
   };
 
   # fix packaging.ParserSyntaxError, which can't handle comments