diff --git a/pkgs/development/python-modules/blosc2/default.nix b/pkgs/development/python-modules/blosc2/default.nix
index 8b8108c5c41e..906127d9bb94 100644
--- a/pkgs/development/python-modules/blosc2/default.nix
+++ b/pkgs/development/python-modules/blosc2/default.nix
@@ -7,22 +7,19 @@
   cmake,
   cython,
   ninja,
-  oldest-supported-numpy,
   pkg-config,
-  scikit-build,
-  setuptools,
-  wheel,
+  scikit-build-core,
 
-  # c library
+  # native dependencies
   c-blosc2,
 
-  # propagates
+  # dependencies
+  httpx,
   msgpack,
   ndindex,
   numexpr,
   numpy,
   py-cpuinfo,
-  rich,
 
   # tests
   psutil,
@@ -32,46 +29,41 @@
 
 buildPythonPackage rec {
   pname = "blosc2";
-  version = "2.7.1";
+  version = "3.0.0";
   pyproject = true;
 
   src = fetchFromGitHub {
     owner = "Blosc";
     repo = "python-blosc2";
     tag = "v${version}";
-    hash = "sha256-2aLfyd+/I8cy9OqdU4yNXY/bkf0AdXu+hZPLDdM3g5g=";
+    hash = "sha256-em03vwTPURkyZfGdlgpoy8QUzbib9SlcR73vYznlsYA=";
   };
 
-  postPatch = ''
-    substituteInPlace requirements-runtime.txt \
-      --replace "pytest" ""
-  '';
-
   pythonRelaxDeps = [ "numpy" ];
 
   nativeBuildInputs = [
     cmake
-    cython
     ninja
-    oldest-supported-numpy
     pkg-config
-    scikit-build
-    setuptools
-    wheel
+  ];
+
+  dontUseCmakeConfigure = true;
+  env.CMAKE_ARGS = lib.cmakeBool "USE_SYSTEM_BLOSC2" true;
+
+  build-system = [
+    cython
+    scikit-build-core
   ];
 
   buildInputs = [ c-blosc2 ];
 
-  dontUseCmakeConfigure = true;
-  env.CMAKE_ARGS = "-DUSE_SYSTEM_BLOSC2:BOOL=YES";
-
-  propagatedBuildInputs = [
+  dependencies = [
+    httpx
     msgpack
     ndindex
     numexpr
     numpy
     py-cpuinfo
-    rich
   ];
 
   nativeCheckInputs = [
@@ -80,12 +72,20 @@ buildPythonPackage rec {
     torch
   ];
 
+  disabledTests = [
+    # RuntimeError: Error while getting the slice
+    "test_lazyexpr"
+    "test_eval_item"
+    # RuntimeError: Error while creating the NDArray
+    "test_lossy"
+  ];
+
   passthru.c-blosc2 = c-blosc2;
 
   meta = with lib; {
     description = "Python wrapper for the extremely fast Blosc2 compression library";
     homepage = "https://github.com/Blosc/python-blosc2";
-    changelog = "https://github.com/Blosc/python-blosc2/releases/tag/v${version}";
+    changelog = "https://github.com/Blosc/python-blosc2/releases/tag/${src.tag}";
     license = licenses.bsd3;
     maintainers = with maintainers; [ ris ];
   };