diff --git a/pkgs/by-name/de/deno/package.nix b/pkgs/by-name/de/deno/package.nix
index b23cd1616f13..a9388f6ad64e 100644
--- a/pkgs/by-name/de/deno/package.nix
+++ b/pkgs/by-name/de/deno/package.nix
@@ -56,10 +56,20 @@ rustPlatform.buildRustPackage (finalAttrs: {
     ./tests-darwin-differences.patch
     ./tests-no-chown.patch
   ];
-  postPatch = ''
-    # Use patched nixpkgs libffi in order to fix https://github.com/libffi/libffi/pull/857
-    tomlq -ti '.workspace.dependencies.libffi = { "version": .workspace.dependencies.libffi, "features": ["system"] }' Cargo.toml
-  '';
+  postPatch =
+    ''
+      # Use patched nixpkgs libffi in order to fix https://github.com/libffi/libffi/pull/857
+      tomlq -ti '.workspace.dependencies.libffi = { "version": .workspace.dependencies.libffi, "features": ["system"] }' Cargo.toml
+    ''
+    +
+      lib.optionalString
+        (stdenv.hostPlatform.isLinux || (stdenv.hostPlatform.isDarwin && stdenv.hostPlatform.isx86_64))
+        ''
+          # LTO crashes with the latest Rust + LLVM combination.
+          # https://github.com/rust-lang/rust/issues/141737
+          # TODO: remove this once LLVM is upgraded to 20.1.7
+          tomlq -ti '.profile.release.lto = false' Cargo.toml
+        '';
 
   buildInputs = [
     libffi