diff --git a/pkgs/by-name/dd/ddev/cli-system-plugin-dir-from-env.patch b/pkgs/by-name/dd/ddev/cli-system-plugin-dir-from-env.patch
new file mode 100644
index 000000000000..4e0705df3b2d
--- /dev/null
+++ b/pkgs/by-name/dd/ddev/cli-system-plugin-dir-from-env.patch
@@ -0,0 +1,31 @@
+diff --git a/cli-plugins/manager/manager_unix.go b/cli-plugins/manager/manager_unix.go
+index f546dc3849..5e3ae08dbc 100644
+--- a/cli-plugins/manager/manager_unix.go
++++ b/cli-plugins/manager/manager_unix.go
+@@ -2,6 +2,11 @@
+ 
+ package manager
+ 
++import (
++	"os"
++	"path/filepath"
++)
++
+ // defaultSystemPluginDirs are the platform-specific locations to search
+ // for plugins in order of preference.
+ //
+@@ -12,9 +17,8 @@
+ // 3. Platform-specific defaultSystemPluginDirs (as defined below).
+ //
+ // [ConfigFile.CLIPluginsExtraDirs]: https://pkg.go.dev/github.com/docker/cli@v26.1.4+incompatible/cli/config/configfile#ConfigFile.CLIPluginsExtraDirs
+-var defaultSystemPluginDirs = []string{
+-	"/usr/local/lib/docker/cli-plugins",
+-	"/usr/local/libexec/docker/cli-plugins",
+-	"/usr/lib/docker/cli-plugins",
+-	"/usr/libexec/docker/cli-plugins",
++var defaultSystemPluginDirs []string
++
++func init() {
++	defaultSystemPluginDirs = filepath.SplitList(os.Getenv("DOCKER_CLI_PLUGIN_DIRS"))
+ }
+
diff --git a/pkgs/by-name/dd/ddev/package.nix b/pkgs/by-name/dd/ddev/package.nix
index f08789fabcb6..4fa3e20b55da 100644
--- a/pkgs/by-name/dd/ddev/package.nix
+++ b/pkgs/by-name/dd/ddev/package.nix
@@ -2,12 +2,22 @@
   lib,
   stdenv,
   buildGoModule,
+  docker-buildx,
   fetchFromGitHub,
   installShellFiles,
+  makeBinaryWrapper,
   versionCheckHook,
   writableTmpDirAsHomeHook,
 }:
 
+let
+  dockerCliPlugins = [
+    docker-buildx
+  ];
+  dockerCliPluginsDirs = lib.strings.concatStringsSep ":" (
+    map (p: "${p}/libexec/docker/cli-plugins") dockerCliPlugins
+  );
+in
 buildGoModule (finalAttrs: {
   pname = "ddev";
   version = "1.25.1";
@@ -19,7 +29,12 @@ buildGoModule (finalAttrs: {
     hash = "sha256-kHGGUFX/xlmQsYxKPxSuRJHk2na9gU1Kd2jhNclAp5s=";
   };
 
+  postPatch = ''
+    (cd vendor/github.com/docker/cli && patch ${./cli-system-plugin-dir-from-env.patch})
+  '';
+
   nativeBuildInputs = [
+    makeBinaryWrapper
     installShellFiles
   ];
 
@@ -34,7 +49,13 @@ buildGoModule (finalAttrs: {
   # Tests need docker.
   doCheck = false;
 
-  postInstall = lib.optionalString (stdenv.buildPlatform.canExecute stdenv.hostPlatform) ''
+  postInstall = ''
+    # make buildx available, it is a docker plugin which docker-compose uses and thus DDEV requires
+    # https://github.com/NixOS/nixpkgs/blob/43fc054052db6ca5df042dcbe823740aa6c9a7c2/pkgs/applications/virtualization/docker/default.nix#L339
+    wrapProgram $out/bin/ddev \
+      --prefix DOCKER_CLI_PLUGIN_DIRS : "${dockerCliPluginsDirs}"
+  ''
+  + lib.optionalString (stdenv.buildPlatform.canExecute stdenv.hostPlatform) ''
     # DDEV will try to create $HOME/.ddev, so we set $HOME to a temporary
     # directory.
     export HOME=$(mktemp -d)