diff --git a/pkgs/by-name/gf/gfortran16/package.nix b/pkgs/by-name/gf/gfortran16/package.nix
new file mode 100644
index 000000000000..4236e7c7716a
--- /dev/null
+++ b/pkgs/by-name/gf/gfortran16/package.nix
@@ -0,0 +1,10 @@
+{ wrapCC, gcc16 }:
+wrapCC (
+  gcc16.cc.override {
+    name = "gfortran";
+    langFortran = true;
+    langCC = false;
+    langC = false;
+    profiledCompiler = false;
+  }
+)
diff --git a/pkgs/development/compilers/gcc/patches/default.nix b/pkgs/development/compilers/gcc/patches/default.nix
index 17d8b9590ead..5be64c16ce84 100644
--- a/pkgs/development/compilers/gcc/patches/default.nix
+++ b/pkgs/development/compilers/gcc/patches/default.nix
@@ -58,6 +58,16 @@ optionals noSysDirs (
   ]
   ++ (
     {
+      "16" = [
+        # Do not try looking for binaries and libraries in /lib and /usr/lib
+        ./13/no-sys-dirs-riscv.patch
+        # Mangle the nix store hash in __FILE__ to prevent unneeded runtime references
+        #
+        # TODO: Remove these and the `useMacroPrefixMap` conditional
+        # in `cc-wrapper` once <https://gcc.gnu.org/PR111527>
+        # is fixed.
+        ./13/mangle-NIX_STORE-in-__FILE__.patch
+      ];
       "15" = [
         # Do not try looking for binaries and libraries in /lib and /usr/lib
         ./13/no-sys-dirs-riscv.patch
diff --git a/pkgs/development/compilers/gcc/versions.nix b/pkgs/development/compilers/gcc/versions.nix
index 521d129bbb37..ca6b2c91033d 100644
--- a/pkgs/development/compilers/gcc/versions.nix
+++ b/pkgs/development/compilers/gcc/versions.nix
@@ -1,5 +1,6 @@
 let
   majorMinorToVersionMap = {
+    "16" = "16.1.0";
     "15" = "15.2.0";
     "14" = "14.3.0";
     "13" = "13.4.0";
@@ -13,6 +14,7 @@ let
     {
       # 3 digits: releases (14.2.0)
       # 4 digits: snapshots (14.2.1.20250322)
+      "16.1.0" = "sha256-UO+02Uwzl6/zsNYaWr10i03THZ0/Kre+BbFx02pRD3k=";
       "15.2.0" = "sha256-Q4/ZloJrDIJIWinaA6ctcdbjVBqD7HAt9Ccfb+Al0k4=";
       "14.3.0" = "sha256-4Nx3KXYlYxrI5Q+pL//v6Jmk63AlktpcMu8E4ik6yjo=";
       "13.4.0" = "sha256-nEzm27BAVo/cVFWIrAPFy8lajb8MeqSQFwhDr7WcqPU=";
diff --git a/pkgs/top-level/ada-packages.nix b/pkgs/top-level/ada-packages.nix
index 729e7045154c..1a4cf5f751c1 100644
--- a/pkgs/top-level/ada-packages.nix
+++ b/pkgs/top-level/ada-packages.nix
@@ -21,9 +21,14 @@ makeScopeWithSplicing' {
 
       xmlada = self.callPackage ../development/ada-modules/xmlada { };
 
-      gnatprove = self.callPackage ../development/ada-modules/gnatprove {
-        ocamlPackages = pkgs.ocaml-ng.ocamlPackages_4_14;
-      };
+      gnatprove =
+        # They haven't released a version of gnatprove for gnat16 yet
+        if lib.versionOlder gnat.version "16" then
+          self.callPackage ../development/ada-modules/gnatprove {
+            ocamlPackages = pkgs.ocaml-ng.ocamlPackages_4_14;
+          }
+        else
+          null;
 
       gnatcoll-core = self.callPackage ../development/ada-modules/gnatcoll/core.nix { };
 
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 680b8cec248f..6e50c31a5bdb 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -3731,6 +3731,7 @@ with pkgs;
   gcc13Stdenv = overrideCC gccStdenv buildPackages.gcc13;
   gcc14Stdenv = overrideCC gccStdenv buildPackages.gcc14;
   gcc15Stdenv = overrideCC gccStdenv buildPackages.gcc15;
+  gcc16Stdenv = overrideCC gccStdenv buildPackages.gcc16;
 
   # This is not intended for use in nixpkgs but for providing a faster-running
   # compiler to nixpkgs users by building gcc with reproducibility-breaking
@@ -3833,9 +3834,10 @@ with pkgs;
     gcc13
     gcc14
     gcc15
+    gcc16
     ;
 
-  gcc_latest = gcc15;
+  gcc_latest = gcc16;
 
   libgccjit = gcc.cc.override {
     name = "libgccjit";
@@ -3933,6 +3935,34 @@ with pkgs;
     }
   );
 
+  gnat16 = wrapCC (
+    gcc16.cc.override {
+      name = "gnat";
+      langC = true;
+      langCC = false;
+      langAda = true;
+      profiledCompiler = false;
+      # As per upstream instructions building a cross compiler
+      # should be done with a (native) compiler of the same version.
+      # If we are cross-compiling GNAT, we may as well do the same.
+      gnat-bootstrap =
+        if stdenv.hostPlatform == stdenv.targetPlatform && stdenv.buildPlatform == stdenv.hostPlatform then
+          buildPackages.gnat-bootstrap14
+        else
+          buildPackages.gnat16;
+      stdenv =
+        if
+          stdenv.hostPlatform == stdenv.targetPlatform
+          && stdenv.buildPlatform == stdenv.hostPlatform
+          && stdenv.buildPlatform.isDarwin
+          && stdenv.buildPlatform.isx86_64
+        then
+          overrideCC stdenv gnat-bootstrap14
+        else
+          stdenv;
+    }
+  );
+
   gnat-bootstrap = gnat-bootstrap13;
   gnat-bootstrap13 = wrapCCWith (
     {
@@ -3954,6 +3984,7 @@ with pkgs;
   gnat13Packages = recurseIntoAttrs (callPackage ./ada-packages.nix { gnat = buildPackages.gnat13; });
   gnat14Packages = recurseIntoAttrs (callPackage ./ada-packages.nix { gnat = buildPackages.gnat14; });
   gnat15Packages = recurseIntoAttrs (callPackage ./ada-packages.nix { gnat = buildPackages.gnat15; });
+  gnat16Packages = recurseIntoAttrs (callPackage ./ada-packages.nix { gnat = buildPackages.gnat16; });
   gnatPackages = gnat13Packages;
 
   inherit (gnatPackages)
@@ -4021,6 +4052,21 @@ with pkgs;
     }
   );
 
+  gccgo16 = wrapCC (
+    gcc16.cc.override {
+      name = "gccgo";
+      langCC = true; # required for go.
+      langC = true;
+      langGo = true;
+      langJit = true;
+      profiledCompiler = false;
+    }
+    // {
+      # not supported on darwin: https://github.com/golang/go/issues/463
+      meta.broken = stdenv.hostPlatform.isDarwin;
+    }
+  );
+
   ghdl-mcode = ghdl.override { backend = "mcode"; };
 
   ghdl-gcc = ghdl.override { backend = "gcc"; };