diff --git a/pkgs/by-name/al/alerta/package.nix b/pkgs/by-name/al/alerta/package.nix
index 5211f0bb37fe..aa6d71e48641 100644
--- a/pkgs/by-name/al/alerta/package.nix
+++ b/pkgs/by-name/al/alerta/package.nix
@@ -25,8 +25,6 @@ python3.pkgs.buildPythonApplication rec {
 
   doCheck = false;
 
-  disabled = python3.pythonOlder "3.6";
-
   meta = {
     homepage = "https://alerta.io";
     description = "Alerta Monitoring System command-line interface";
diff --git a/pkgs/by-name/go/gorilla-cli/package.nix b/pkgs/by-name/go/gorilla-cli/package.nix
index 55686538c4ad..589f33e292e7 100644
--- a/pkgs/by-name/go/gorilla-cli/package.nix
+++ b/pkgs/by-name/go/gorilla-cli/package.nix
@@ -17,8 +17,6 @@ python3.pkgs.buildPythonApplication rec {
     hash = "sha256-3h3QtBDKswTDL7zNM2C4VWiGCqknm/bxhP9sw4ieIcQ=";
   };
 
-  disabled = python3.pythonOlder "3.6";
-
   build-system = with python3.pkgs; [
     setuptools
   ];
diff --git a/pkgs/by-name/ni/nimbo/package.nix b/pkgs/by-name/ni/nimbo/package.nix
index 42d2a9bd8d00..661db2d69d89 100644
--- a/pkgs/by-name/ni/nimbo/package.nix
+++ b/pkgs/by-name/ni/nimbo/package.nix
@@ -11,7 +11,6 @@ python3.pkgs.buildPythonApplication rec {
   pname = "nimbo";
   version = "0.3.0";
   format = "setuptools";
-  disabled = python3.pythonOlder "3.6";
 
   src = fetchFromGitHub {
     owner = "nimbo-sh";
diff --git a/pkgs/by-name/py/pylode/package.nix b/pkgs/by-name/py/pylode/package.nix
index 7356f3b5b987..099007f6a661 100644
--- a/pkgs/by-name/py/pylode/package.nix
+++ b/pkgs/by-name/py/pylode/package.nix
@@ -9,8 +9,6 @@ python3.pkgs.buildPythonApplication rec {
   version = "2.13.3";
   pyproject = true;
 
-  disabled = python3.pythonOlder "3.6";
-
   src = fetchFromGitHub {
     owner = "RDFLib";
     repo = "pylode";
diff --git a/pkgs/by-name/sh/shot-scraper/package.nix b/pkgs/by-name/sh/shot-scraper/package.nix
index 5052334b68ed..4818f015a263 100644
--- a/pkgs/by-name/sh/shot-scraper/package.nix
+++ b/pkgs/by-name/sh/shot-scraper/package.nix
@@ -9,8 +9,6 @@ python3.pkgs.buildPythonApplication rec {
   version = "1.8";
   pyproject = true;
 
-  disabled = python3.pkgs.pythonOlder "3.6";
-
   src = fetchFromGitHub {
     owner = "simonw";
     repo = "shot-scraper";
diff --git a/pkgs/by-name/us/usbrip/package.nix b/pkgs/by-name/us/usbrip/package.nix
index 9ec88c6d4cad..11e25d1053b6 100644
--- a/pkgs/by-name/us/usbrip/package.nix
+++ b/pkgs/by-name/us/usbrip/package.nix
@@ -9,8 +9,6 @@ python3.pkgs.buildPythonApplication {
   version = "0-unstable-2021-07-02";
   pyproject = true;
 
-  disabled = python3.pythonOlder "3.6";
-
   src = fetchFromGitHub {
     owner = "snovvcrash";
     repo = "usbrip";
diff --git a/pkgs/by-name/xx/xxh/package.nix b/pkgs/by-name/xx/xxh/package.nix
index e9a9b4da45c1..70e6e5b5e098 100644
--- a/pkgs/by-name/xx/xxh/package.nix
+++ b/pkgs/by-name/xx/xxh/package.nix
@@ -9,7 +9,6 @@ python3.pkgs.buildPythonApplication rec {
   pname = "xxh";
   version = "0.8.14";
   pyproject = true;
-  disabled = python3.pkgs.pythonOlder "3.6";
 
   src = fetchFromGitHub {
     owner = "xxh";
diff --git a/pkgs/development/python-modules/augmax/default.nix b/pkgs/development/python-modules/augmax/default.nix
index 2ddb285b7061..9573bd29a870 100644
--- a/pkgs/development/python-modules/augmax/default.nix
+++ b/pkgs/development/python-modules/augmax/default.nix
@@ -5,7 +5,6 @@
   jax,
   jaxlib,
   lib,
-  pythonOlder,
   setuptools,
 }:
 
@@ -14,8 +13,6 @@ buildPythonPackage rec {
   version = "0.3.3";
   pyproject = true;
 
-  disbaled = pythonOlder "3.6";
-
   src = fetchFromGitHub {
     owner = "khdlr";
     repo = "augmax";
diff --git a/pkgs/development/python-modules/bwapy/default.nix b/pkgs/development/python-modules/bwapy/default.nix
index 11b27dcfd2c5..6de156ff9d2e 100644
--- a/pkgs/development/python-modules/bwapy/default.nix
+++ b/pkgs/development/python-modules/bwapy/default.nix
@@ -2,7 +2,6 @@
   lib,
   buildPythonPackage,
   pythonAtLeast,
-  pythonOlder,
   fetchPypi,
   bwa,
   cffi,
@@ -15,7 +14,7 @@ buildPythonPackage rec {
   format = "setuptools";
 
   # uses the removed imp module
-  disabled = pythonOlder "3.6" || pythonAtLeast "3.12";
+  disabled = pythonAtLeast "3.12";
 
   src = fetchPypi {
     inherit pname version;
diff --git a/pkgs/development/python-modules/future-fstrings/default.nix b/pkgs/development/python-modules/future-fstrings/default.nix
index 6e2782b698ee..949532f3a24a 100644
--- a/pkgs/development/python-modules/future-fstrings/default.nix
+++ b/pkgs/development/python-modules/future-fstrings/default.nix
@@ -2,7 +2,6 @@
   lib,
   buildPythonPackage,
   fetchPypi,
-  pythonOlder,
 }:
 
 buildPythonPackage rec {
@@ -25,6 +24,5 @@ buildPythonPackage rec {
     mainProgram = "future-fstrings-show";
     license = lib.licenses.mit;
     maintainers = with lib.maintainers; [ nyanloutre ];
-    broken = pythonOlder "3.6"; # dependency tokenize-rt not packaged
   };
 }
diff --git a/pkgs/development/python-modules/irctokens/default.nix b/pkgs/development/python-modules/irctokens/default.nix
index 4155ef180a28..ac9afc7274ff 100644
--- a/pkgs/development/python-modules/irctokens/default.nix
+++ b/pkgs/development/python-modules/irctokens/default.nix
@@ -2,7 +2,6 @@
   lib,
   buildPythonPackage,
   fetchFromGitHub,
-  pythonOlder,
   setuptools,
   pyyaml,
   unittestCheckHook,
@@ -13,8 +12,6 @@ buildPythonPackage rec {
   version = "2.0.2";
   pyproject = true;
 
-  disabled = pythonOlder "3.6"; # f-strings
-
   src = fetchFromGitHub {
     owner = "jesopo";
     repo = "irctokens";
diff --git a/pkgs/development/python-modules/pandas-datareader/default.nix b/pkgs/development/python-modules/pandas-datareader/default.nix
index aaf21fa3b025..08c97850568a 100644
--- a/pkgs/development/python-modules/pandas-datareader/default.nix
+++ b/pkgs/development/python-modules/pandas-datareader/default.nix
@@ -1,7 +1,6 @@
 {
   lib,
   buildPythonPackage,
-  pythonOlder,
   pythonAtLeast,
   fetchPypi,
   setuptools,
@@ -15,7 +14,7 @@ buildPythonPackage rec {
   version = "0.10.0";
   pyproject = true;
 
-  disabled = pythonOlder "3.6" || pythonAtLeast "3.12";
+  disabled = pythonAtLeast "3.12";
 
   src = fetchPypi {
     inherit pname version;
diff --git a/pkgs/development/python-modules/preprocess-cancellation/default.nix b/pkgs/development/python-modules/preprocess-cancellation/default.nix
index 3c21dd84ec48..f19608992fe0 100644
--- a/pkgs/development/python-modules/preprocess-cancellation/default.nix
+++ b/pkgs/development/python-modules/preprocess-cancellation/default.nix
@@ -1,7 +1,6 @@
 {
   lib,
   buildPythonPackage,
-  pythonOlder,
   fetchFromGitHub,
   poetry-core,
   shapely,
@@ -11,7 +10,6 @@
 buildPythonPackage rec {
   pname = "preprocess-cancellation";
   version = "0.2.1";
-  disabled = pythonOlder "3.6"; # >= 3.6
   pyproject = true;
 
   # No tests in PyPI
diff --git a/pkgs/development/python-modules/python-socks/default.nix b/pkgs/development/python-modules/python-socks/default.nix
index 022aca1ca197..3e844a037dc9 100644
--- a/pkgs/development/python-modules/python-socks/default.nix
+++ b/pkgs/development/python-modules/python-socks/default.nix
@@ -21,8 +21,6 @@ buildPythonPackage rec {
   version = "2.7.3";
   pyproject = true;
 
-  disabled = pythonOlder "3.6.2";
-
   __darwinAllowLocalNetworking = true;
 
   src = fetchFromGitHub {
diff --git a/pkgs/development/python-modules/pytomlpp/default.nix b/pkgs/development/python-modules/pytomlpp/default.nix
index 02cd9bc95a61..4866d8469ee5 100644
--- a/pkgs/development/python-modules/pytomlpp/default.nix
+++ b/pkgs/development/python-modules/pytomlpp/default.nix
@@ -2,7 +2,6 @@
   lib,
   buildPythonPackage,
   fetchFromGitHub,
-  pythonOlder,
   pybind11,
   pytestCheckHook,
   python-dateutil,
@@ -40,8 +39,7 @@ buildPythonPackage rec {
     matplotlib
   ];
 
-  # pelican requires > 2.7
-  doCheck = !pythonOlder "3.6";
+  doCheck = true;
 
   disabledTests = [
     # incompatible with pytest7
diff --git a/pkgs/development/python-modules/pytz-deprecation-shim/default.nix b/pkgs/development/python-modules/pytz-deprecation-shim/default.nix
index dc52cab267e7..d9258a6ebc82 100644
--- a/pkgs/development/python-modules/pytz-deprecation-shim/default.nix
+++ b/pkgs/development/python-modules/pytz-deprecation-shim/default.nix
@@ -2,9 +2,6 @@
   lib,
   buildPythonPackage,
   fetchPypi,
-  pythonAtLeast,
-  pythonOlder,
-  python-dateutil,
   setuptools,
   tzdata,
   hypothesis,
@@ -26,9 +23,7 @@ buildPythonPackage rec {
 
   nativeBuildInputs = [ setuptools ];
 
-  propagatedBuildInputs =
-    (lib.optionals (pythonOlder "3.6") [ python-dateutil ])
-    ++ (lib.optionals (pythonAtLeast "3.6") [ tzdata ]);
+  propagatedBuildInputs = [ tzdata ];
 
   nativeCheckInputs = [
     hypothesis
diff --git a/pkgs/development/python-modules/skybellpy/default.nix b/pkgs/development/python-modules/skybellpy/default.nix
index 767e020d9be3..76e58efe547a 100644
--- a/pkgs/development/python-modules/skybellpy/default.nix
+++ b/pkgs/development/python-modules/skybellpy/default.nix
@@ -7,7 +7,6 @@
   pytest-timeout,
   pytestCheckHook,
   pythonAtLeast,
-  pythonOlder,
   requests,
   requests-mock,
   setuptools,
@@ -19,7 +18,7 @@ buildPythonPackage rec {
   pyproject = true;
 
   # Still uses distrutils, https://github.com/MisterWil/skybellpy/issues/22
-  disabled = pythonOlder "3.6" || pythonAtLeast "3.12";
+  disabled = pythonAtLeast "3.12";
 
   src = fetchFromGitHub {
     owner = "MisterWil";
diff --git a/pkgs/development/python-modules/tensorflow/default.nix b/pkgs/development/python-modules/tensorflow/default.nix
index 370ad401586f..d4d8e8fa85c5 100644
--- a/pkgs/development/python-modules/tensorflow/default.nix
+++ b/pkgs/development/python-modules/tensorflow/default.nix
@@ -13,7 +13,6 @@
   # Python deps
   buildPythonPackage,
   pythonAtLeast,
-  pythonOlder,
   python,
   # Python libraries
   numpy,
@@ -132,7 +131,7 @@ let
     }
   ];
 
-  withTensorboard = (pythonOlder "3.6") || tensorboardSupport;
+  withTensorboard = tensorboardSupport;
 
   cudaComponents = with cudaPackages; [
     (cuda_nvcc.__spliced.buildHost or cuda_nvcc)
diff --git a/pkgs/development/python-modules/vmprof/default.nix b/pkgs/development/python-modules/vmprof/default.nix
index 181a319b8321..7a5d69e3a6fb 100644
--- a/pkgs/development/python-modules/vmprof/default.nix
+++ b/pkgs/development/python-modules/vmprof/default.nix
@@ -1,7 +1,6 @@
 {
   lib,
   buildPythonPackage,
-  pythonOlder,
   pythonAtLeast,
   fetchFromGitHub,
   setuptools,
@@ -18,7 +17,7 @@ buildPythonPackage rec {
   version = "0.4.17";
   pyproject = true;
 
-  disabled = pythonOlder "3.6" || pythonAtLeast "3.12";
+  disabled = pythonAtLeast "3.12";
 
   src = fetchFromGitHub {
     owner = "vmprof";
diff --git a/pkgs/development/python2-modules/pytest/default.nix b/pkgs/development/python2-modules/pytest/default.nix
index 21a1967e837c..3adb0a7d4aad 100644
--- a/pkgs/development/python2-modules/pytest/default.nix
+++ b/pkgs/development/python2-modules/pytest/default.nix
@@ -1,7 +1,6 @@
 {
   lib,
   buildPythonPackage,
-  pythonOlder,
   fetchPypi,
   attrs,
   hypothesis,
@@ -16,7 +15,6 @@
   atomicwrites,
   mock,
   writeText,
-  pathlib2,
   wcwidth,
   packaging,
   isPyPy,
@@ -52,8 +50,7 @@ buildPythonPackage rec {
     wcwidth
     packaging
   ]
-  ++ lib.optionals (!isPy3k) [ funcsigs ]
-  ++ lib.optionals (pythonOlder "3.6") [ pathlib2 ];
+  ++ lib.optionals (!isPy3k) [ funcsigs ];
 
   doCheck = !isPyPy; # https://github.com/pytest-dev/pytest/issues/3460
   checkPhase = ''
diff --git a/pkgs/development/python2-modules/typing/default.nix b/pkgs/development/python2-modules/typing/default.nix
index 5cc48c6b12e8..66104f8dc24d 100644
--- a/pkgs/development/python2-modules/typing/default.nix
+++ b/pkgs/development/python2-modules/typing/default.nix
@@ -2,11 +2,8 @@
   lib,
   buildPythonPackage,
   fetchPypi,
-  pythonOlder,
   isPy3k,
-  isPyPy,
   unittestCheckHook,
-  pythonAtLeast,
 }:
 
 let
@@ -23,12 +20,7 @@ buildPythonPackage rec {
     sha256 = "13b4ad211f54ddbf93e5901a9967b1e07720c1d1b78d596ac6a439641aa1b130";
   };
 
-  disabled = pythonAtLeast "3.5";
-
-  # Error for Python3.6: ImportError: cannot import name 'ann_module'
-  # See https://github.com/python/typing/pull/280
-  # Also, don't bother on PyPy: AssertionError: TypeError not raised
-  doCheck = pythonOlder "3.6" && !isPyPy;
+  disabled = true;
 
   nativeCheckInputs = [ unittestCheckHook ];