diff --git a/doc/release-notes/rl-2605.section.md b/doc/release-notes/rl-2605.section.md
index 2f228659cd19..4c4d9024a8a9 100644
--- a/doc/release-notes/rl-2605.section.md
+++ b/doc/release-notes/rl-2605.section.md
@@ -13,6 +13,8 @@
 
 - All Log4Shell vulnerability scanners were removed, as they were all unmaintained upstream and are no longer relevant given that the vulnerability has been fixed upstream for several years.
 
+- `python3packages.pillow-avif-plugin` has been removed as the functionality is included in `python3packages.pillow` directly since version 11.3.
+
 ## Other Notable Changes {#sec-nixpkgs-release-26.05-notable-changes}
 
 <!-- To avoid merge conflicts, consider adding your item at an arbitrary place in the list instead. -->
diff --git a/pkgs/development/python-modules/pillow-avif-plugin/default.nix b/pkgs/development/python-modules/pillow-avif-plugin/default.nix
deleted file mode 100644
index 4f06ceba1bb5..000000000000
--- a/pkgs/development/python-modules/pillow-avif-plugin/default.nix
+++ /dev/null
@@ -1,37 +0,0 @@
-{
-  lib,
-  buildPythonPackage,
-  fetchFromGitHub,
-  setuptools,
-  libavif,
-  pillow,
-  pytestCheckHook,
-}:
-
-buildPythonPackage rec {
-  pname = "pillow-avif-plugin";
-  version = "1.5.2";
-  pyproject = true;
-
-  src = fetchFromGitHub {
-    owner = "fdintino";
-    repo = "pillow-avif-plugin";
-    tag = "v${version}";
-    hash = "sha256-gdDVgVNympxlTzj1VUqO+aU1/xWNjDm97a0biOTlKtA=";
-  };
-
-  build-system = [ setuptools ];
-
-  buildInputs = [ libavif ];
-
-  dependencies = [ pillow ];
-
-  nativeCheckInputs = [ pytestCheckHook ];
-
-  meta = {
-    description = "Pillow plugin that adds support for AVIF files";
-    homepage = "https://github.com/fdintino/pillow-avif-plugin";
-    license = lib.licenses.bsd2;
-    maintainers = with lib.maintainers; [ ratcornu ];
-  };
-}
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index 48ba2eec63c6..08f56d34bae7 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -299,6 +299,7 @@ mapAliases {
   pdfminer = throw "'pdfminer' has been renamed to/replaced by 'pdfminer-six'"; # Converted to throw 2025-10-29
   pep257 = throw "'pep257' has been renamed to/replaced by 'pydocstyle'"; # Converted to throw 2025-10-29
   percol = throw "percol has been removed because it hasn't been updated since 2019"; # added 2025-05-25
+  pillow-avif-plugin = throw "'pillow-avif-plugin' has been removed because 'pillow' has native avif support since 11.3"; # added 2025-11-26
   plumlightpad = throw "plumlightpad has been removed because the API was shut down"; # added 2025-11-04
   Polygon3 = throw "'Polygon3' has been renamed to/replaced by 'polygon3'"; # Converted to throw 2025-10-29
   posix_ipc = throw "'posix_ipc' has been renamed to/replaced by 'posix-ipc'"; # Converted to throw 2025-10-29
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index cdce69e04eca..cb0aa4b1b9c3 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -12005,8 +12005,6 @@ self: super: with self; {
     inherit (pkgs.xorg) libxcb;
   };
 
-  pillow-avif-plugin = callPackage ../development/python-modules/pillow-avif-plugin { };
-
   pillow-heif = callPackage ../development/python-modules/pillow-heif { };
 
   pillow-jpls = callPackage ../development/python-modules/pillow-jpls { };