diff --git a/pkgs/by-name/gr/graphviz/package.nix b/pkgs/by-name/gr/graphviz/package.nix
index f5686e0274d3..0ee2c6b0f129 100644
--- a/pkgs/by-name/gr/graphviz/package.nix
+++ b/pkgs/by-name/gr/graphviz/package.nix
@@ -22,6 +22,7 @@
   libxrender,
   python3,
   withXorg ? true,
+  withQuartz ? false,
 
   # for passthru.tests
   exiv2,
@@ -75,7 +76,8 @@ stdenv.mkDerivation (finalAttrs: {
     "--with-ltdl-lib=${libtool.lib}/lib"
     "--with-ltdl-include=${libtool}/include"
     (lib.withFeature withXorg "x")
-  ];
+  ]
+  ++ optional withQuartz "--with-quartz";
 
   enableParallelBuilding = true;
   strictDeps = true;
diff --git a/pkgs/development/python-modules/pygraphviz/default.nix b/pkgs/development/python-modules/pygraphviz/default.nix
index c6b365bf23f1..e32c63e89ef4 100644
--- a/pkgs/development/python-modules/pygraphviz/default.nix
+++ b/pkgs/development/python-modules/pygraphviz/default.nix
@@ -3,6 +3,7 @@
   buildPythonPackage,
   fetchFromGitHub,
   replaceVars,
+  stdenv,
   graphviz,
   coreutils,
   pkg-config,
@@ -11,6 +12,10 @@
   pytest,
 }:
 
+let
+  # TODO: remove once #540793 makes it to master
+  graphviz' = graphviz.override { withQuartz = stdenv.hostPlatform.isDarwin; };
+in
 buildPythonPackage (finalAttrs: {
   pname = "pygraphviz";
   version = "2.0";
@@ -27,7 +32,7 @@ buildPythonPackage (finalAttrs: {
     # pygraphviz depends on graphviz executables and wc being in PATH
     (replaceVars ./path.patch {
       path = lib.makeBinPath [
-        graphviz
+        graphviz'
         coreutils
       ];
     })
@@ -38,19 +43,19 @@ buildPythonPackage (finalAttrs: {
       --replace-fail ', "swig>4.1.0"' ""
   '';
 
-  env.GRAPHVIZ_PREFIX = graphviz;
+  env.GRAPHVIZ_PREFIX = graphviz';
 
   build-system = [
     setuptools
   ];
 
   nativeBuildInputs = [
-    graphviz # for dot
+    graphviz' # for dot
     pkg-config
     swig
   ];
 
-  buildInputs = [ graphviz ];
+  buildInputs = [ graphviz' ];
 
   nativeCheckInputs = [ pytest ];