diff --git a/pkgs/development/python-modules/asdf-astropy/default.nix b/pkgs/development/python-modules/asdf-astropy/default.nix
index b1b171796591..db48ba6979e9 100644
--- a/pkgs/development/python-modules/asdf-astropy/default.nix
+++ b/pkgs/development/python-modules/asdf-astropy/default.nix
@@ -30,6 +30,11 @@ buildPythonPackage rec {
     hash = "sha256-JYzC1dEnq1caNSPffWCgk7c3mgUERywP0ladS+RwEnk=";
   };
 
+  postPatch = ''
+    # pytest chokes on unhandled options in the [tool.pytest.ini_options] section
+    sed -i "/asdf_schema_/d" pyproject.toml
+  '';
+
   build-system = [
     setuptools
     setuptools-scm