diff --git a/pkgs/development/python-modules/pyoxigraph/default.nix b/pkgs/development/python-modules/pyoxigraph/default.nix
new file mode 100644
index 000000000000..29115fa8573a
--- /dev/null
+++ b/pkgs/development/python-modules/pyoxigraph/default.nix
@@ -0,0 +1,70 @@
+{
+  stdenv,
+  apple-sdk_15,
+  buildPythonPackage,
+  fetchFromGitHub,
+  lib,
+  pkg-config,
+  pythonOlder,
+  pytestCheckHook,
+  rustPlatform,
+}:
+buildPythonPackage rec {
+  pname = "pyoxigraph";
+  pyproject = true;
+  version = "0.4.8";
+
+  src = fetchFromGitHub {
+    owner = "oxigraph";
+    repo = "oxigraph";
+    tag = "v${version}";
+    fetchSubmodules = true;
+    hash = "sha256-yMXNt7pGiwYDXjmHxKUQpqNrAmnFpg21Vc5R1DmwsHc=";
+  };
+
+  cargoDeps = rustPlatform.fetchCargoVendor {
+    inherit pname version src;
+    hash = "sha256-qOGpM3SOAOMO5W3wj4ruXlymp9bV4sqOU75gMVSEyfk=";
+  };
+
+  buildAndTestSubdir = "python";
+
+  dependencies = lib.optionals stdenv.hostPlatform.isDarwin [
+    apple-sdk_15
+  ];
+
+  disabled = pythonOlder "3.8";
+
+  disabledTests = [
+    "test_update_load"
+  ];
+
+  disabledTestPaths = [
+    # These require network access
+    "lints/test_spec_links.py"
+    "lints/test_debian_compatibility.py"
+    "oxrocksdb-sys/rocksdb/tools/block_cache_analyzer/block_cache_pysim_test.py"
+    "oxrocksdb-sys/rocksdb/tools"
+  ];
+
+  nativeBuildInputs = [
+    pkg-config
+    rustPlatform.bindgenHook
+    rustPlatform.cargoSetupHook
+    rustPlatform.maturinBuildHook
+  ];
+
+  nativeCheckInputs = [ pytestCheckHook ];
+  pythonImportsCheck = [ "pyoxigraph" ];
+
+  meta = {
+    homepage = "https://github.com/oxigraph/oxigraph";
+    description = "SPARQL graph database";
+    maintainers = with lib.maintainers; [ dadada ];
+    license = with lib.licenses; [
+      asl20
+      mit
+    ];
+    platforms = lib.platforms.unix;
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 0b97a88a7f24..459ee752b591 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -12643,6 +12643,8 @@ self: super: with self; {
 
   pyowm = callPackage ../development/python-modules/pyowm { };
 
+  pyoxigraph = callPackage ../development/python-modules/pyoxigraph { };
+
   pypager = callPackage ../development/python-modules/pypager { };
 
   pypamtest = toPythonModule (pkgs.libpam-wrapper.override {