diff --git a/pkgs/development/python-modules/scikit-image/default.nix b/pkgs/development/python-modules/scikit-image/default.nix
index 9c3583fe365a..b06c1cb5db48 100644
--- a/pkgs/development/python-modules/scikit-image/default.nix
+++ b/pkgs/development/python-modules/scikit-image/default.nix
@@ -1,4 +1,5 @@
 { lib
+, stdenv
 , fetchFromGitHub
 , buildPythonPackage
 , python
@@ -63,13 +64,18 @@ in buildPythonPackage rec {
     # Requires network access (actually some data is loaded via `skimage._shared.testing.fetch` in the global scope, which calls `pytest.skip` when a network is unaccessible, leading to a pytest collection error).
     "${installedPackageRoot}/skimage/filters/rank/tests/test_rank.py"
   ];
-  pytestFlagsArray = [ "${installedPackageRoot}" "--pyargs" "skimage" ] ++ builtins.map (testid: "--deselect=" + testid) [
+  pytestFlagsArray = [ "${installedPackageRoot}" "--pyargs" "skimage" ] ++ builtins.map (testid: "--deselect=" + testid) ([
     # These tests require network access
     "skimage/data/test_data.py::test_skin"
     "skimage/data/tests/test_data.py::test_skin"
     "skimage/io/tests/test_io.py::test_imread_http_url"
     "skimage/restoration/tests/test_rolling_ball.py::test_ndim"
-  ];
+  ] ++ lib.optionals stdenv.isDarwin [
+    # Matplotlib tests are broken inside darwin sandbox
+    "skimage/feature/tests/test_util.py::test_plot_matches"
+    "skimage/filters/tests/test_thresholding.py::TestSimpleImage::test_try_all_threshold"
+    "skimage/io/tests/test_mpl_imshow.py::"
+  ]);
 
   # Check cythonized modules
   pythonImportsCheck = [