diff --git a/pkgs/development/python-modules/primer3/default.nix b/pkgs/development/python-modules/primer3/default.nix
index b2999f582455..78d43a08b4ac 100644
--- a/pkgs/development/python-modules/primer3/default.nix
+++ b/pkgs/development/python-modules/primer3/default.nix
@@ -7,12 +7,13 @@
 , click
 , pytestCheckHook
 , pythonOlder
+, setuptools
 }:
 
 buildPythonPackage rec {
   pname = "primer3";
-  version = "2.0.2";
-  format = "setuptools";
+  version = "2.0.3";
+  pyproject = true;
 
   disabled = pythonOlder "3.7";
 
@@ -20,11 +21,12 @@ buildPythonPackage rec {
     owner = "libnano";
     repo = "primer3-py";
     rev = "refs/tags/v${version}";
-    hash = "sha256-v3y9nJpWc9lBKcPX/qjuezjfK0nzKIMiE0QdoLgyNj8=";
+    hash = "sha256-O8BFjkjG9SfknSrK34s9EJnqTrtCf4zW9A+N+/MHl2w=";
   };
 
   nativeBuildInputs = [
     cython
+    setuptools
   ] ++ lib.optionals stdenv.isDarwin [
     gcc
   ];